Evidence map›Paper›PMID 39364398›Full record

ArticleFrontiers in immunology2024

Case report: Artificial thymic organoids facilitate clinical decisions for a patient with a

Alevtina Gall, Marita Bosticardo, Stacey Ma, Karin Chen, Kayla Amini, Francesca Pala, Ottavia M Delmonte, Tara Wenger, Michael Bamshad, John Sleasman and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Informed clinical decisions by outfoxing human FOXN1 variants.The Journal of allergy and clinical immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alevtina GallDivision of Immunology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, United States.
Marita BosticardoLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, United States.
Stacey MaDivision of Allergy and Infectious Diseases, Department of Internal Medicine, University of Washington, Seattle, WA, United States.
Karin ChenDivision of Immunology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, United States.
Kayla AminiLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, United States.
Francesca PalaLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, United States.
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, United States.
Tara WengerDivision of Genetic Medicine, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, United States.
Michael BamshadDivision of Genetic Medicine, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, United States.
John SleasmanDepartment of Pediatrics, Duke University Medical Center, Durham, NC, United States.
Matthew BlessingDivision of Craniofacial Medicine, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, United States.
Nicolai S C van OersDepartment of Immunology, Pediatrics and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, United States.
M Teresa de la MorenaDivision of Immunology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic variants in the transcription factor

Indexed as

LymphopeniaOrganoidsThymus GlandTranscription FactorsTumor Suppressor ProteinsCell DifferentiationChild, PreschoolFemaleHumansMutationT-LymphocytesTP63 protein, humanTranscription FactorsTumor Suppressor Proteinsankyloblepharon-ectodermal defects-cleft lip/palate (AEC)artificial thymic organoidscultured thymus tissue implantation (CTTI)ectrodactyly-ectodermal dysplasia clefting (EEC)T cell lymphopeniaTP63

Identifiers

PMID39364398
PMCPMC11448704

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.