ArticleNature synthesis2024
Engineering non-haem iron enzymes for enantioselective C(sp3)-F bond formation via radical fluorine transfer.
Article in Nature synthesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- A binuclear copper enzyme platform for enantioconvergent radical (pseudo)halogenation.bioRxiv : the preprint server for biology · 2026Article
- Directed evolution of an enantiocomplementary SNature communications · 2026Article
- Experimental and Computational Elucidation of C(sp3)-H Fluorination Barriers in an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase.Journal of the American Chemical Society · 2026Article
- Influence of Primary Coordination Sphere on Anion Rebound Selectivity in Nonheme Fe Enzyme-Catalyzed C(sp3)-H Functionalization: A Comparative Experimental and Computational Study of EgtB and ACCO.Journal of the American Chemical Society · 2026Article
- Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme.Chemical science · 2026Article
- Reprogramming Imine Reductases for Enantioselective Reduction of Electron-Rich Enamides.JACS Au · 2026Article
- N-Heterocyclic Carbene (NHC) Catalysis in Enzymatic Organic Synthesis.Coordination chemistry reviews · 2026Article
- Nonheme Fe Enzyme-Catalyzed Enantiodivergent Nitrogen Migration: Directed Evolution and Computational Study of Isopenicillin N Synthases for Biocatalytic Synthesis of Arylglycines.Angewandte Chemie (International ed. in English) · 2026Article
- Examining Pseudohalide (NJournal of inorganic biochemistry · 2026Article
- Harnessing Photoenzymatic Systems for Intermolecular C-H Fluorination.Angewandte Chemie (International ed. in English) · 2026Article
- Biocatalytic Synthesis of N-Protected α-Amino Acids through 1,3-Nitrogen Migration by Nonheme Iron Enzymes.Journal of the American Chemical Society · 2025Article
- Non-heme iron enzymes step into the spotlight.Nature chemical biology · 2025Article
- Nonheme Fe 1,3-nitrogen migratases for asymmetric noncanonical amino acid synthesis.Nature chemical biology · 2025Article
- Biocatalytic Olefin Difunctionalization for Synthesis of Chiral 2-Azidoamines Using Nonheme Iron Enzymes.Angewandte Chemie (International ed. in English) · 2025Article
- Directed Evolution of Nonheme Iron Enzymes for Enantioselective Aminative Difunctionalization of Alkenes.JACS Au · 2025Article
- Recent advances in natural and synthetic phosphonate therapeutics.Current opinion in microbiology · 2025Review
- Directed Evolution of Copper-Substituted Nonheme Enzymes for Enantioselective Alkene Oxytrifluoromethylation.Journal of the American Chemical Society · 2025Article
- Enantioconvergent benzylic C(spScience (New York, N.Y.) · 2025Article
- Cooperative Photometallobiocatalysis: Nonheme Fe Enzyme-Catalyzed Enantioconvergent Radical Decarboxylative Azidation, Thiocyanation, and Isocyanation of Redox-Active Esters.Angewandte Chemie (International ed. in English) · 2025Article
- Photoenzymatic enantioselective synthesis of fluorinated amides with remote stereocenter.Nature communications · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
In recent years there has been a surge in the development of methods for the synthesis of organofluorine compounds. However, enzymatic methods for C-F bond formation have been limited to nucleophilic fluoride substitution. Here, we report the incorporation of iron-catalysed radical fluorine transfer, a reaction mechanism that is not used in naturally occurring enzymes, into enzymatic catalysis for the development of biocatalytic enantioselective C(
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