Evidence map›Paper›PMID 39363878›Full record

ArticleDevelopment and psychopathology2025

Intergenerational transmission of comorbid internalizing and externalizing psychopathology at age 11: Evidence from an adoption design for general transmission of comorbidity rather than homotypic transmission.

Kristine Marceau, Sohee Lee, Muskan Datta, Olivia C Robertson, Daniel S Shaw, Misaki N Natsuaki, Leslie D Leve, Jody M Ganiban, Jenae M Neiderhiser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development and psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristine MarceauDepartment of Human Development and Family Science, Purdue University, West Lafayette, IN, USA.ORCID https://orcid.org/0000-0002-8924-6597
Sohee LeeDepartment of Human Development and Family Science, Purdue University, West Lafayette, IN, USA.
Muskan DattaDepartment of Human Development and Family Science, Purdue University, West Lafayette, IN, USA.
Olivia C RobertsonDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.
Daniel S ShawDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-9111-9258
Misaki N NatsuakiDepartment of Psychology, University of California, Riverside, CA, USA.
Leslie D LevePrevention Science Institute, University of Oregon, Eugene, OR, USA.ORCID https://orcid.org/0000-0003-3061-4524
Jody M GanibanDepartment of Psychology, George Washington University, WashingtonWA, DC, USA.ORCID https://orcid.org/0000-0001-5908-6644
Jenae M NeiderhiserDepartment of Psychology, Penn State University, University Park, PA, USA.ORCID https://orcid.org/0000-0003-4474-5330

Funding

The Early Growth and Development Study Pediatric CohortUH3OD023389 · OD · UNIVERSITY OF OREGON · PI Jody M. Ganiban, Leslie Diane Leve · 2018 to 2026
$16.6M
The Early Growth and Development Study: Family Process, Genes and School EntryR01HD042608 · NICHD · OREGON SOCIAL LEARNING CENTER, INC. · PI CAPALDI, DEBORAH M. · 2002 to 2011
$14.9M
The Early Growth and Development Study Pediatric CohortUG3OD023389 · OD · UNIVERSITY OF OREGON · PI GANIBAN, JODY M., LEVE, LESLIE DIANE · 2016 to 2024
$7.5M
Genes, Prenatal Drug Exposure, and the Postnatal Environment: An Adoption StudyR01DA020585 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI NEIDERHISER, JENAE M. · 2007 to 2011
$5.9M
An adoption study of the development of early substance use: the joint roles of genetic influences, prenatal risk, rearing environment, and pubertal maturationR01DA045108 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI NEIDERHISER, JENAE M. · 2018 to 2022
$3.7M
Gene-Environment Interplay and Development of Psychiatric Symptoms in ChildrenR01MH092118 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LEVE, LESLIE DIANE, NEIDERHISER, JENAE M. · 2010 to 2014
$3.1M
NICHD NIH HHS R01 HD042608NIDA NIH HHS R01 DA020585NIDA NIH HHS R01 DA045108NIH HHS UG3 OD023389NIH HHS UH3 OD023389NIMH NIH HHS R01 MH092118
6 · The paper itself

Abstract

Psychopathology is intergenerationally transmitted through both genetic and environmental mechanisms via heterotypic (cross-domain), homotypic (domain-specific), and general (e.g., "p-factor") pathways. The current study leveraged an adopted-at-birth design, the Early Growth and Development Study (57% male; 55.6% White, 19.3% Multiracial, 13% Black/African American, 10.9% Hispanic/Latine) to explore the relative influence of these pathways via associations between adoptive caregiver psychopathology (indexing potential environmental transmission) and birth parent psychopathology (indexing genetic transmission) with adolescent internalizing and externalizing symptoms. We included composite measures of adoptive and birth parent internalizing, externalizing, and substance use domains, and a general "p-factor." Age 11 adolescent internalizing and externalizing symptom scores were the average of adoptive parent reports on the Child Behavior Checklist (

Indexed as

AdoptionMental DisordersAdolescentChildComorbidityFemaleHumansMaleParentsadoption designcomorbidityintergenerational transmissioninternalizing and externalizingseverity and directionality

Identifiers

PMID39363878
PMCPMC11968446

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.