Evidence map›Paper›PMID 39363401›Full record

ArticleHead & neck2025

Development of a Preclinical Double Model of Mandibular Irradiated Bone and Osteoradionecrosis in New Zealand Rabbits.

Alessandra Ruaro, Stefano Taboni, Harley H L Chan, Tiziana Mondello, Patricia Lindsay, Teesha Komal, Lara Alessandrini, Marta Sbaraglia, Elena Bellan, Roberto Maroldi and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Alessandra RuaroGuided Therapeutics (GTx) Program, International Scholarship Program, Techna Institute, University Health Network, Toronto, Ontario, Canada.
Stefano TaboniGuided Therapeutics (GTx) Program, International Scholarship Program, Techna Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-2407-4031
Harley H L ChanGuided Therapeutics (GTx) Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Tiziana MondelloSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padova, Padova, Italy.
Patricia LindsayDepartment of Radiation Oncology, Radiation Physics, and Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.
Teesha KomalSpatio-Temporal Targeting and Amplification of Radiation (STTARR) Innovation Centre, University Health Network, Toronto, Ontario, Canada.
Lara AlessandriniDepartment of Medicine (DIMED), University of Padova, Padova, Italy.
Marta SbaragliaDepartment of Medicine (DIMED), University of Padova, Padova, Italy.
Elena BellanDepartment of Medicine (DIMED), University of Padova, Padova, Italy.
Roberto MaroldiRadiology Unit, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Jason TownsonGuided Therapeutics (GTx) Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Michael J DalyGuided Therapeutics (GTx) Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Federica ReUnit of Blood Diseases and Bone Marrow Transplantation, Department of Clinical and Experimental Sciences, ASST Spedali Civili, University of Brescia, Brescia, Italy.
Chiara PasiniDepartment of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy.
Marco KrengliRadiotherapy Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.
Luciana SartoreDepartment of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy.
Domenico RussoUnit of Blood Diseases and Bone Marrow Transplantation, Department of Clinical and Experimental Sciences, ASST Spedali Civili, University of Brescia, Brescia, Italy.
Piero NicolaiSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padova, Padova, Italy.
Marco FerrariGuided Therapeutics (GTx) Program, International Scholarship Program, Techna Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-4023-0121
Ralph W GilbertPrincess Margaret Cancer Centre/Toronto General Hospital, Department of Otolaryngology-Head and Neck Surgery/Surgical Oncology, University Health Network, Toronto, Ontario, Canada.
Jonathan C IrishGuided Therapeutics (GTx) Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Funding

Princess Margaret Cancer Foundation
6 · The paper itself

Abstract

purposeRadiotherapy (RT) plays a crucial role in head and neck (HN) cancer treatment. Nevertheless, it can lead to serious and challenging adverse events such as osteoradionecrosis (ORN). A preclinical rabbit model of irradiated bone and ORN is herein proposed, with the aim to develop a viable model to be exploited for investigating new therapeutic approaches.

methodsNine New Zealand white rabbits were irradiated using a single beam positioned to the left of the mandible and directed perpendicular to the left mandible. A 10 × 10 mm

resultsRadiological signs suggestive for ORN were detected in the entire population (100%) 16 weeks after irradiation on ROI

conclusionsA preclinical double model was successfully developed. The side receiving the higher dose showed radiological and histological signs of bone damage, resulting in an ORN model. Whereas the contralateral side, receiving the lower dose, presented with histological damage only and a normal radiological appearance. This work describes the creation of a double model, an ORN and irradiated bone model, for further study using this animal species.

Indexed as

Disease Models, AnimalMandibleOsteoradionecrosisAnimalsDose-Response Relationship, RadiationMandibular DiseasesRabbitsRadiotherapy Dosageexperimental animal modelshead and neckmandibular irradiationosteoradionecrosisradiotherapy

Identifiers

PMID39363401
PMCPMC11717962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.