Evidence map›Paper›PMID 39363383›Full record

ArticleTrials2024

Integrating the Memory Support Intervention into the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C): can improving memory for treatment in midlife and older adults improve patient outcomes? Study protocol for a randomized controlled trial.

Anne E Milner, Rafael Esteva Hache, Sophia Oliver, Laurel D Sarfan, Julia M Spencer, Ashby Cogan, Yimei Jiang, Emma R Agnew, Garret G Zieve, Jennifer L Martin and 8 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05986604 (NIA_Improving Sleep and Circadian Functioning, Daytime Functioning, and Well-being for Midlife and Older Adults by Improving Patient Memory for a Transdiagnostic Sleep and Circadian Treatment), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05986604 narecruitingnot on this map

NIA_Improving Sleep and Circadian Functioning, Daytime Functioning, and Well-being for Midlife and Older Adults by Improving Patient Memory for a Transdiagnostic Sleep and Circadian Treatment

TypeinterventionalSponsorUniversity of California, BerkeleyRan2024 to 2028Enrolled178ConditionsSleep Disorder, Circadian Dysregulation, Memory ImpairmentArmsMemory Support Intervention, Transdiagnostic Intervention for Sleep and Circadian Dysfunction
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anne E MilnerDepartment of Psychology, University of California, Berkeley, CA, USA.
Rafael Esteva HacheDepartment of Psychology, University of California, Berkeley, CA, USA.
Sophia OliverDepartment of Psychology, University of California, Berkeley, CA, USA.
Laurel D SarfanDepartment of Psychology, University of California, Berkeley, CA, USA.
Julia M SpencerDepartment of Psychology, University of California, Berkeley, CA, USA.
Ashby CoganDepartment of Psychology, University of California, Berkeley, CA, USA.
Yimei JiangDepartment of Psychology, University of California, Berkeley, CA, USA.
Emma R AgnewDepartment of Psychology, University of California, Berkeley, CA, USA.
Garret G ZieveOakland Cognitive Behavior Therapy Center, Oakland, CA, USA.
Jennifer L MartinGeriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, USA.
Michelle R ZeidlerUCLA Health Pulmonology, Los Angeles, CA, USA.
Lu DongBehavioral and Policy Sciences, RAND Corporation, Santa Monica, CA, USA.
Joseph K CarpenterNational Center for PTSD, Women's Health Sciences Division, VA Boston Healthcare System, Boston, MA, USA.
Joshua VargheseDepartment of Psychology, University of California, Berkeley, CA, USA.
Kiely BolDepartment of Psychology, University of California, Berkeley, CA, USA.
Zia BajwaDepartment of Psychology, University of California, Berkeley, CA, USA.
Caitlan A TigheDepartment of Psychology, Providence College, Providence, RI, USA.
Allison G HarveyDepartment of Psychology, University of California, Berkeley, CA, USA. aharvey@berkeley.edu.ORCID http://orcid.org/0000-0002-8609-0005

Funding

Improving sleep and circadian functioning, daytime functioning, and well-being for midlife and older adults by improving patient memory for a transdiagnostic sleep and circadian treatmentR01AG082651 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Allison G Harvey · 2023 to 2026
$2.5M
UC Davis Advancing Diversity in the Neuroscience Research (ADNR) ProgramR25NS112130 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI USREY, W MARTIN · 2019 to 2023
$1.2M
NIA NIH HHS R01 AG082651NINDS NIH HHS R25 NS112130
6 · The paper itself

Abstract

backgroundPoor memory for treatment is associated with poorer treatment adherence and poorer patient outcomes. The memory support intervention (MSI) was developed to improve patient memory for treatment with the goal of improving patient outcomes. The aim of this study protocol is to conduct a confirmatory efficacy trial to test whether a new, streamlined, and potent version of the MSI improves outcomes for midlife and older adults. This streamlined MSI is comprised of constructive memory supports that will be applied to a broader range of treatment content. The platform for this study is the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C). We will focus on midlife and older adults who are low income and experiencing mobility impairments.

methodsParticipants (N = 178) will be randomly allocated to TranS-C + MSI or TranS-C alone. Both intervention arms include eight 50-min weekly sessions. Assessments will be conducted at pre-treatment, post-treatment, 6-, and 12-month follow-up (6FU and 12FU). Aim 1 will compare the effects of TranS-C + MSI versus TranS-C alone on sleep and circadian functioning, daytime functioning, well-being, and patient memory. Aim 2 will test whether patient memory for treatment mediates the relationship between treatment condition and patient outcomes. Aim 3 will evaluate if previously reported poor treatment response subgroups will moderate the relationship between treatment condition and (a) patient memory for treatment and (b) treatment outcome. Exploratory analyses will compare treatment condition on (a) patient adherence, patient-rated treatment credibility, and patient utilization of treatment contents, and (b) provider-rated acceptability, appropriateness, and feasibility. DISCUSSION: This study has the potential to provide evidence for (a) the efficacy of a new simplified version of the MSI for maintaining health, well-being, and functioning, (b) the wider application of the MSI for midlife and older adults and to the treatment of sleep and circadian problems, and (c) the efficacy of the MSI for sub-groups who are likely to benefit from the intervention.

trial registrationClinicalTrials.gov NCT05986604. Registered on 2 August 2023.

Indexed as

MemoryRandomized Controlled Trials as TopicSleepAgedAge FactorsChronobiology DisordersCircadian RhythmFemaleHumansMaleMemory DisordersMiddle AgedSleep QualitySleep Wake DisordersTreatment OutcomeCircadianMemory supportSleepTransdiagnostic

Identifiers

PMID39363383
PMCPMC11448292

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.