Evidence map›Paper›PMID 39363292›Full record

ArticleInflammation and regeneration2024

Deletion of TP signaling in macrophages delays liver repair following APAP-induced liver injury by reducing accumulation of reparative macrophage and production of HGF.

Mina Tanabe, Kanako Hosono, Atsushi Yamashita, Yoshiya Ito, Masataka Majima, Shuh Narumiya, Chika Kusano, Hideki Amano

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In one paragraph

Article in Inflammation and regeneration, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mina TanabeDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Kanako HosonoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Atsushi YamashitaDepartment of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Yoshiya ItoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Masataka MajimaDepartment of Medical Therapeutics, Kanagawa Institute of Technology, Atsugi, Japan.
Shuh NarumiyaDepartment of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Chika KusanoDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.
Hideki AmanoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan. hideki@med.kitasato-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcetaminophen (APAP)-induced liver injury is the most common cause of acute liver failure. Macrophages are key players in liver restoration following APAP-induced liver injury. Thromboxane A

methodsMale TP knockout (TP

resultsCompared with WT mice, TP

conclusionsDeletion of TP signaling in macrophages delays liver repair following APAP-induced liver injury, which is associated with reduced accumulation of reparative macrophages and the hepatotrophic factor HGF. Specific activation of TP signaling in macrophages may be a potential therapeutic target for liver repair and regeneration after APAP hepatotoxicity.

Indexed as

AcetaminophenLiver repairMacrophageThromboxane

Identifiers

PMID39363292
PMCPMC11451145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.