Evidence map›Paper›PMID 39362977›Full record

ArticleCommunications biology2024

Cyclo(Pro-Tyr) elicits conserved cellular damage in fungi by targeting the [H

D Vela-Corcia, J Hierrezuelo, A I Pérez-Lorente, P Stincone, A K Pakkir Shah, A Grélard, Y Zi-Long, A de Vicente, A Pérez García, L Bai and 3 more

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

D Vela-CorciaInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento de Microbiología, Universidad de Málaga, Málaga, Spain.
J HierrezueloInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento de Microbiología, Universidad de Málaga, Málaga, Spain.
A I Pérez-LorenteInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento de Microbiología, Universidad de Málaga, Málaga, Spain.
P StinconeUniversity of Tuebingen, CMFI Cluster of Excellence, Interfaculty Institute of Microbiology and Infection Medicine, Tuebingen, Germany.
A K Pakkir ShahUniversity of Tuebingen, CMFI Cluster of Excellence, Interfaculty Institute of Microbiology and Infection Medicine, Tuebingen, Germany.ORCID 0000-0002-5629-8331
A GrélardL'Institut de Chimie et Biologie des Membranes et des Nano-Objets (CBMN), Unité Mixte de Recherche (UMR) 5248, Centre National de la Recherche (CNRS), University of Bordeaux, Pessac, France.ORCID 0000-0002-6708-2253
Y Zi-LongDepartment of Biophysics, School of Basic Medical Sciences, Peking University, Beijing, China.
A de VicenteInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento de Microbiología, Universidad de Málaga, Málaga, Spain.ORCID 0000-0003-2716-9861
A Pérez GarcíaInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento de Microbiología, Universidad de Málaga, Málaga, Spain.ORCID 0000-0002-1065-0360
L BaiDepartment of Biophysics, School of Basic Medical Sciences, Peking University, Beijing, China.
A LoquetL'Institut de Chimie et Biologie des Membranes et des Nano-Objets (CBMN), Unité Mixte de Recherche (UMR) 5248, Centre National de la Recherche (CNRS), University of Bordeaux, Pessac, France.ORCID 0000-0001-7176-7813
D PetrasUniversity of Tuebingen, CMFI Cluster of Excellence, Interfaculty Institute of Microbiology and Infection Medicine, Tuebingen, Germany.ORCID 0000-0002-6561-3022
D RomeroInstituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento de Microbiología, Universidad de Málaga, Málaga, Spain. diego_romero@uma.es.ORCID 0000-0002-2052-6515

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) BacBio 637971Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness) PID2019-107724GB-I00
6 · The paper itself

Abstract

Bioactive metabolites play a crucial role in shaping interactions among diverse organisms. In this study, we identified cyclo(Pro-Tyr), a metabolite produced by Bacillus velezensis, as a potent inhibitor of Botrytis cinerea and Caenorhabditis elegans, two potential cohabitant eukaryotic organisms. Based on our investigation, cyclo(Pro-Tyr) disrupts plasma membrane polarization, induces oxidative stress and increases membrane fluidity, which compromises fungal membrane integrity. These cytological and physiological changes induced by cyclo(Pro-Tyr) may be triggered by the destabilization of membrane microdomains containing the [H

Indexed as

BotrytisCaenorhabditis elegansCell MembraneProton-Translocating ATPasesAnimalsAntifungal AgentsMembrane MicrodomainsOxidative StressReactive Oxygen SpeciesAntifungal AgentsProton-Translocating ATPasesReactive Oxygen Species

Identifiers

PMID39362977
PMCPMC11449911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.