Evidence map›Paper›PMID 39362952›Full record

ArticleScientific reports2024

Risk of Parkinson's disease in spinal cord injury: a nationwide cohort study in South Korea.

Jong Hyeon Ahn, Bong-Seong Kim, Kyung-Do Han, Hea Lim Choi, Wonyoung Jung, Jin Whan Cho, Jinyoung Youn, Dong Wook Shin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jong Hyeon AhnDepartment of Neurology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
Bong-Seong KimDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, 06978, South Korea.
Kyung-Do HanDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, 06978, South Korea.
Hea Lim ChoiDepartment of Family Medicine/Executive Healthcare Clinic, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Wonyoung JungDepartment of Family Medicine, Kangdong Sacred Heart Hospital, 150, Seongan-ro, Gangdong- gu, Seoul, 05355, South Korea.
Jin Whan ChoDepartment of Neurology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
Jinyoung YounDepartment of Neurology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. genian@skku.edu.
Dong Wook ShinDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute of Health Science and Technology (SAIHST), Sungkyunkwan University, Seoul, 06355, South Korea. dwshin.md@gmail.com.

Funding

Korea Health Industry Development Institute HI20C1073Korea Health Industry Development Institute RS-2023-00266288
6 · The paper itself

Abstract

Despite the association between spinal cord injury (SCI) and various neurological diseases, the risk of Parkinson's disease (PD) in SCI is not elucidated yet. Especially, the role of SCI severity and injury level in the risk of PD development is not investigated. Based on the nation-wide cohort data the Korean National Health Insurance Service between 2010 and 2018, we investigated the incidence of PD in 7,182 patients with SCI compared with 24,844 age- and sex-matched controls. Adjusted hazard ratio and 95% confidence interval (CI) were calculated using Cox proportional hazards regression. We compared the risk of PD based on the degree of disability (without disability, mild, severe) and SCI level (cervical, thoracic, and lumbar). During the mean follow-up duration of 4.31 years, patients with SCI had a higher risk of PD compared with matched controls. The PD risk was greater among patients with SCI with disability than in those without disability, especially those with mild disability. Additionally, cervical-level injury was associated with the highest risk in patients with SCI without disability, while thoracic-level injury was associated with the highest risk in those with disability. Our study found patients with SCI have increased risk of PD, particularly those with disability and thoracic-level injuries.

Indexed as

Parkinson DiseaseSpinal Cord InjuriesAdultAgedCase-Control StudiesCohort StudiesFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRepublic of KoreaRisk FactorsKoreaNationwide studyParkinsonParkinson’s diseasePhysical disabilitySpinal cord injury

Identifiers

PMID39362952
PMCPMC11450175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.