Evidence map›Paper›PMID 39362939›Full record

ArticleScientific reports2024

Relationship between dietary sialic acid intake and serum HbA1c: a population-based study in Xiamen, China.

Zecheng Zhou, Wei Zhang, Xinyue Wang, Wanqiu Sha, Zhikun Xu, Hongwei Li, Jiale Huang

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zecheng Zhou *State Key Laboratory of Vaccines for Infectious Diseases, Xiang-An Biomedicine Laboratory, School of Public Health, Xiamen University, 361101, Xiamen, China.
Wei Zhang *State Key Laboratory of Vaccines for Infectious Diseases, Xiang-An Biomedicine Laboratory, School of Public Health, Xiamen University, 361101, Xiamen, China.
Xinyue WangDepartment of Nutrition, Zhongshan Hospital (Xiamen), Fudan University, 361000, Xiamen, Fujian province, China.
Wanqiu ShaState Key Laboratory of Vaccines for Infectious Diseases, Xiang-An Biomedicine Laboratory, School of Public Health, Xiamen University, 361101, Xiamen, China.
Zhikun XuState Key Laboratory of Vaccines for Infectious Diseases, Xiang-An Biomedicine Laboratory, School of Public Health, Xiamen University, 361101, Xiamen, China.
Hongwei LiState Key Laboratory of Vaccines for Infectious Diseases, Xiang-An Biomedicine Laboratory, School of Public Health, Xiamen University, 361101, Xiamen, China. rocque@xmu.edu.cn.
Jiale HuangDepartment of Clinical Nutrition, Jiangxi Medical College, Nanchang University, 330006, Nanchang, Jiangxi Province, China. jialezs1030@163.com.

Funding

Xiamen University, China Project 2023Y1540
6 · The paper itself

Abstract

This study investigates the correlation between dietary sialic acid intake which mainly come from eggs, red meat, and dairy products and serum HbA1c levels. A survey among Xiamen's general population, China, collected dietary data from 2,908 participants over the past year. A semi-quantitative food frequency questionnaire (FFQ) was employed. Sialic acid intake was calculated, along with measurements of biochemical indicators, including fasting blood glucose, HbA1c, blood lipids, and insulin. Sociodemographic and physical data were also collected. Logistic regression models evaluated the relationship between dietary sialic acid and HbA1c levels. The daily sialic acid intake in Xiamen's general population was 48.55 (21.68, 65.23) mg/1000Kcal, accompanied by a 1.96% rate of high HbA1c. A significant negative correlation between dietary sialic acid and HbA1c was observed. Individuals in the highest quartile of sialic acid intake (> 65.48 mg/1000 kcal) had a lower risk of high HbA1c compared to those in the lowest quartile (< 23.63 mg/1000 kcal) [OR: 0.123 (0.022, 0.689)]. A high dietary sialic acid intake within a specific range may reduce the risk of elevated HbA1c levels, suggesting a potential preventive effect. Note that this effect is limited to specific intake ranges.

Indexed as

DietGlycated HemoglobinN-Acetylneuraminic AcidAdultAgedBlood GlucoseChinaFemaleHumansMaleMiddle AgedBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanN-Acetylneuraminic AcidAdultCross-sectional analysisDietary sialic acidGlycosylated hemoglobinLogistic regression

Identifiers

PMID39362939
PMCPMC11450165

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.