Evidence map›Paper›PMID 39362776›Full record

ArticleGenes & development2024

NEAT1 promotes genome stability via m

Victoria Mamontova, Barbara Trifault, Anne-Sophie Gribling-Burrer, Patrick Bohn, Lea Boten, Pit Preckwinkel, Peter Gallant, Daniel Solvie, Carsten P Ade, Dimitrios Papadopoulos and 4 more

Abstract read
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  9. Review
  10. Article
  11. Review
  12. The crosstalk of mTrends in biochemical sciences · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Victoria MamontovaMildred Scheel Early Career Center for Cancer Research (Mildred-Scheel-Nachwuchszentrum [MSNZ]) Würzburg, University Hospital Würzburg, 97080 Würzburg, Germany.
Barbara TrifaultMildred Scheel Early Career Center for Cancer Research (Mildred-Scheel-Nachwuchszentrum [MSNZ]) Würzburg, University Hospital Würzburg, 97080 Würzburg, Germany.
Anne-Sophie Gribling-BurrerHelmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97808 Würzburg, Germany.
Patrick BohnHelmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97808 Würzburg, Germany.
Lea BotenMildred Scheel Early Career Center for Cancer Research (Mildred-Scheel-Nachwuchszentrum [MSNZ]) Würzburg, University Hospital Würzburg, 97080 Würzburg, Germany.
Pit PreckwinkelDepartment of RNA Biology and Pathogenesis, Institute of Molecular Medicine, Martin Luther University Halle-Wittenberg, Charles Tanford Protein Research Center, 06120 Halle, Germany.
Peter GallantDepartment of Biochemistry and Molecular Biology, Biocenter of the University of Würzburg, 97074 Würzburg, Germany.
Daniel SolvieDepartment of Biochemistry and Molecular Biology, Biocenter of the University of Würzburg, 97074 Würzburg, Germany.
Carsten P AdeDepartment of Biochemistry and Molecular Biology, Biocenter of the University of Würzburg, 97074 Würzburg, Germany.
Dimitrios PapadopoulosDepartment of Biochemistry and Molecular Biology, Biocenter of the University of Würzburg, 97074 Würzburg, Germany.
Martin EilersDepartment of Biochemistry and Molecular Biology, Biocenter of the University of Würzburg, 97074 Würzburg, Germany.
Tony GutschnerDepartment of RNA Biology and Pathogenesis, Institute of Molecular Medicine, Martin Luther University Halle-Wittenberg, Charles Tanford Protein Research Center, 06120 Halle, Germany.
Redmond P SmythHelmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97808 Würzburg, Germany.ORCID 0000-0002-1580-0671
Kaspar BurgerMildred Scheel Early Career Center for Cancer Research (Mildred-Scheel-Nachwuchszentrum [MSNZ]) Würzburg, University Hospital Würzburg, 97080 Würzburg, Germany; kaspar.burger@uni-wuerzburg.de.ORCID 0000-0003-0587-9782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding (lnc)RNAs emerge as regulators of genome stability. The nuclear-enriched abundant transcript 1 (NEAT1) is overexpressed in many tumors and is responsive to genotoxic stress. However, the mechanism that links NEAT1 to DNA damage response (DDR) is unclear. Here, we investigate the expression, modification, localization, and structure of NEAT1 in response to DNA double-strand breaks (DSBs). DNA damage increases the levels and N6-methyladenosine (m

Indexed as

AdenosineDNA Breaks, Double-StrandedGenomic InstabilityMethyltransferasesRNA, Long NoncodingDNA DamageDNA HelicasesGene Expression RegulationHistonesHumansMethylationAdenosineDNA HelicasesHistonesMethyltransferasesMETTL3 protein, humanNEAT1 long non-coding RNA, humanN-methyladenosineRNA, Long NoncodingCHD4DNA damage responseDNA double-strand breakslong noncoding RNAMETTL3NEAT1paraspeckles

Identifiers

PMID39362776
PMCPMC11535147

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.