Evidence map›Paper›PMID 39362647›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2024

Roles of ZEB1 and ZEB2 in E-cadherin expression and cell aggressiveness in head and neck cancer.

Arisa Kinouchi, Takahiro Jubashi, Rikito Tatsuno, Jiro Ichikawa, Kaname Sakamoto, Daiju Sakurai, Tomonori Kawasaki, Hiroki Ishii, Keiji Miyazawa, Masao Saitoh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Roles of ZEB1 and ZEB2 in E-cadherin expression and cell aggressiveness in head and neck cancer.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arisa KinouchiDepartment of Biochemistry, University of Yamanashi, Chuo, Yamanashi, Japan.
Takahiro JubashiDepartment of Orthopaedic Surgery, University of Yamanashi, Chuo, Yamanashi, Japan.
Rikito TatsunoDepartment of Orthopaedic Surgery, University of Yamanashi, Chuo, Yamanashi, Japan.
Jiro IchikawaDepartment of Orthopaedic Surgery, University of Yamanashi, Chuo, Yamanashi, Japan.
Kaname SakamotoDepartment of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Chuo, Yamanashi, Japan.
Daiju SakuraiDepartment of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Chuo, Yamanashi, Japan.
Tomonori KawasakiDepartment of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.
Hiroki IshiiDepartment of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Chuo, Yamanashi, Japan.
Keiji MiyazawaDepartment of Biochemistry, University of Yamanashi, Chuo, Yamanashi, Japan.
Masao SaitohDepartment of Biochemistry, University of Yamanashi, Chuo, Yamanashi, Japan.ORCID https://orcid.org/0000-0003-0793-1679

Funding

the Japan Society for the Promotion of Science (JSPS) KAKENHI 21K16828the Japan Society for the Promotion of Science (JSPS) KAKENHI 22H03260the Japan Society for the Promotion of Science (JSPS) KAKENHI 23K08959
6 · The paper itself

Abstract

Zinc finger E-box binding homeobox 1 (ZEB1) has been identified as a key factor in cancer cell differentiation and metastasis, and has been well studied in the field of cancer cell biology. ZEB2 has a highly similar conformation to ZEB1, but its role in head and neck squamous cell carcinoma (HNSCC) cells is not fully understood. Here, we separately overexpressed ZEB1 and ZEB2 in C57BL/6 mouse oral cancer (MOC) cells and investigated their cellular characteristics, including E-cadherin levels, motile properties, chemoresistance, and metastatic ability in immunocompetent mice. Both ZEB1 and ZEB2 overexpression reduced epithelial traits and converted cells to an aggressive phenotype. Surprisingly, ZEB1 overexpression increased the endogenous level of ZEB2 in MOC cells, and vice versa. The molecular mechanisms underlying these findings remain unclear. However, the in vitro anchorage-independent growth of MOC cells overexpressing ZEB2 was considerably greater than that of MOC cells overexpressing ZEB1. These findings suggest that ZEB2, like ZEB1, has the ability to induce the differentiation of cancer cells into those with highly aggressive traits.

Indexed as

CadherinsHead and Neck NeoplasmsMice, Inbred C57BLZinc Finger E-box-Binding Homeobox 1Zinc Finger E-box Binding Homeobox 2AnimalsCell Line, TumorCell MovementGene Expression Regulation, NeoplasticHumansMiceCadherinsZEB1 protein, mouseZEB2 protein, mouseZinc Finger E-box-Binding Homeobox 1Zinc Finger E-box Binding Homeobox 2EMThead and neck squamous cell carcinomaZEB1ZEB2

Identifiers

PMID39362647
PMCPMC11609604

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.