Evidence map›Paper›PMID 39362457›Full record

ArticleEnvironmental research2024

Characterization of pesticide exposures and their associations with asthma morbidity in a predominantly low-income urban pediatric cohort in Baltimore City.

Magdalena Fandiño-Del-Rio, Grant Tore, Roger D Peng, John D Meeker, Elizabeth C Matsui, Lesliam Quirós-Alcalá

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Pesticides and human health.Jornal de pediatria
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Magdalena Fandiño-Del-RioDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: mfandin2@jhu.edu.
Grant ToreDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: gtore1@jhu.edu.
Roger D PengDepartment of Statistics and Data Sciences, University of Texas, Austin, TX, USA. Electronic address: roger.peng@austin.utexas.edu.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. Electronic address: meekerj@umich.edu.
Elizabeth C MatsuiDell Medical School, University of Texas, Austin, TX, USA. Electronic address: elizabeth.matsui@austin.utexas.edu.
Lesliam Quirós-AlcaláDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: lquiros@jhu.edu.

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
The effect of a housing mobility program on environmental exposures and asthma morbidity among low-income minority childrenR01ES026170 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI KEET, CORINNE, MATSUI, ELIZABETH C. · 2016 to 2025
$6.8M
The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
Environmental Control as Add-on Therapy in Urban Children with AsthmaR01ES023447 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2014 to 2018
$3.4M
Mentoring in Patient-Oriented Research on Asthma and the Indoor EnvironmentK24AI114769 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MATSUI, ELIZABETH C. · 2015 to 2023
$1.6M
Antimicrobial Agents and Asthma Morbidity among African American Children withAsthmaK01HL138124 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI QUIROS-ALCALA, LESLIAM · 2017 to 2021
$666k
NHLBI NIH HHS K01 HL138124NIAID NIH HHS K24 AI114769NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P50 ES018176NIEHS NIH HHS R01 ES023447NIEHS NIH HHS R01 ES026170NIOSH CDC HHS T42 OH008428
6 · The paper itself

Abstract

backgroundPesticides may impact respiratory health, yet evidence of their impact on pediatric asthma morbidity is limited, particularly among urban children.

objectiveTo characterize pesticide biomarker concentrations and evaluate their associations with pediatric asthma morbidity among predominantly low-income, Black children in Baltimore City, USA.

methodsWe measured urinary concentrations of 10 biomarkers for pyrethroid insecticides (cyfluthrin:4F-3PBA, permethrin:3PBA), organophosphate insecticides (chlorpyrifos:TCPY, malathion:MDA, parathion:PNP, diazinon:IMPY), and herbicides (glyphosate:AMPA, GPS; 2,4-dicholorphenoxyacetic acid:2,4-D; 2,4,5-tricholorphenoxyacetic acid:2,4,5-T) among 148 children (5-17 years) with established asthma. Urine samples and asthma morbidity measures (asthma symptoms, healthcare utilization, lung function and inflammation) were collected every three months for a year. Generalized estimating equations were used to examine associations between pesticide biomarker concentrations and asthma morbidity measures, controlling for age, sex, race, caregiver education, season, and environmental tobacco smoke. In sensitivity analyses, we assessed the robustness of our results after accounting for environmental co-exposures.

resultsFrequently detected (≥90% detection) pesticide biomarker concentrations (IMPY, 3PBA, PNP, TCPY, AMPA, GPS) varied considerably within children over the follow-up period (intraclass correlation coefficients: 0.1-0.2). Consistent positive significant associations were observed between the chlorpyrifos biomarker, TCPY, and asthma symptoms. Urinary concentrations of TCPY were associated with increased odds of coughing, wheezing, or chest tightness (adjusted Odds Ratio, aOR, TCPY:1.60, 95% Confidence Interval, CI:1.17-2.18). Urinary concentrations of TCPY were also associated with maximal symptom days (aOR:1.38, CI:1.02-1.86), exercise-related symptoms (aOR:1.63, CI:1.09-2.44), and hospitalizations for asthma (aOR:2.84, CI:1.08-7.43). We did not observe consistent evidence of associations between the pesticide exposures assessed and lung function or inflammation measures.

conclusionAmong predominantly Black children with asthma, we found evidence that chlorpyrifos is associated with asthma morbidity. Further research is needed to assess the contribution of pesticide exposures to pediatric respiratory health and characterize exposure sources among vulnerable populations to inform targeted interventions against potentially harmful pesticide exposures.

Indexed as

AsthmaBiomarkersEnvironmental ExposurePesticidesAdolescentBaltimoreBlack or African AmericanChildChild, PreschoolCohort StudiesEnvironmental PollutantsFemaleHumansMalePovertyUrban PopulationBiomarkersEnvironmental PollutantsPesticidesExposure assessmentPesticidesRespiratory healthVulnerable populations

Identifiers

PMID39362457
PMCPMC12143413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.