Evidence map›Paper›PMID 39362448›Full record

ArticleActa biomaterialia2024

Type V collagen exhibits distinct regulatory activities in TMJ articular disc versus condylar cartilage during postnatal growth and remodeling.

Prashant Chandrasekaran, Abdulaziz Alanazi, Bryan Kwok, Qing Li, Girish Viraraghavan, Sriram Balasubramanian, David B Frank, X Lucas Lu, David E Birk, Robert L Mauck and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Prashant ChandrasekaranSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Abdulaziz AlanaziSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Bryan KwokSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Qing LiSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Girish ViraraghavanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Sriram BalasubramanianSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
David B FrankPenn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Division of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.
X Lucas LuDepartment of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States.
David E BirkDepartment of Molecular Pharmacology and Physiology, Morsani School of Medicine, University of South Florida, Tampa, FL 33612, United States.
Robert L MauckMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz Veterans Administration Medical Center, Philadelphia, PA 19104, United States.
Nathaniel A DymentMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
Eiki KoyamaDepartment of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.
Lin HanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United States. Electronic address: lh535@drexel.edu.

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Roles of Type V Collagen in the Structure and Biomechanics of TMJ Condylar CartilageR21DE029567 · NIDCR · DREXEL UNIVERSITY · PI HAN, LIN · 2020 to 2021
$445k
NIAMS NIH HHS P30 AR069619NIDCR NIH HHS R21 DE029567
6 · The paper itself

Abstract

Understanding matrix molecular activities that regulate the postnatal growth and remodeling of the temporomandibular joint (TMJ) articular disc and condylar cartilage will enable the development of effective regenerative strategies targeting TMJ disorders. This study elucidated the distinct roles of type V collagen (collagen V) in regulating these two units. Studying the TMJ of young adult Col5a1

Indexed as

Mandibular CondyleTemporomandibular Joint DiscAnimalsCartilage, ArticularCell ProliferationMiceExtracellular matrixFibrocartilageMechanobiologyTemporomandibular jointType V collagen

Identifiers

PMID39362448
PMCPMC11640222

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.