Evidence map›Paper›PMID 39362405›Full record

ArticleContemporary clinical trials2024

A randomized trial of aerobic exercise in colorectal cancer: Rationale, design, recruitment, and exercise adherence results.

Stephanie L E Compton, Shengping Yang, Lauren S Maniscalco, Reem A Muhsen, Pratibha Shrestha, Xiaocheng Wu, Kaylee T Woodard, Elizabeth R M Zunica, Eunhan Cho, Rachel L Wall and 7 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03975491 (The Exercise And Colorectal Cancer Treatment), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03975491 naactive not recruitingnot on this map

The Exercise And Colorectal Cancer Treatment (EXACT) Trial

TypeinterventionalSponsorPennington Biomedical Research CenterRan2019 to 2026Enrolled60ConditionsColon Cancer, Rectal CancerArmsModerate-Intensity Aerobic Exercise, Wait-List Control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stephanie L E ComptonPennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA.
Shengping YangPennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA.
Lauren S ManiscalcoLSU Health Sciences Center, New Orleans School of Public Health, Louisiana Tumor Registry, 2020 Gravier St., New Orleans, LA 70112, USA.
Reem A MuhsenLSU Health Sciences Center, New Orleans School of Public Health, Louisiana Tumor Registry, 2020 Gravier St., New Orleans, LA 70112, USA.
Pratibha ShresthaLSU Health Sciences Center, New Orleans School of Public Health, Louisiana Tumor Registry, 2020 Gravier St., New Orleans, LA 70112, USA.
Xiaocheng WuLSU Health Sciences Center, New Orleans School of Public Health, Louisiana Tumor Registry, 2020 Gravier St., New Orleans, LA 70112, USA.
Kaylee T WoodardPennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA; LSU Health Sciences Center, New Orleans School of Public Health, Louisiana Tumor Registry, 2020 Gravier St., New Orleans, LA 70112, USA.
Elizabeth R M ZunicaPennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA.
Eunhan ChoSchool of Kinesiology, College of Human Sciences & Education, Louisiana State University, Baton Rouge, LA 70802, USA.
Rachel L WallSchool of Kinesiology, College of Human Sciences & Education, Louisiana State University, Baton Rouge, LA 70802, USA.
John BrownPennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA; Louisiana State University Health Shreveport, School of Medicine, 1501 Kings Hwy., Shreveport, LA 71103, USA.
Anjana JayaramanCornell University, 377 Kimball Hall, Ithaca, NY 14853, USA.
Brian J KirbyCornell University, 377 Kimball Hall, Ithaca, NY 14853, USA.
L Anne GilmoreUT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.
Frank L GreenwayPennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA.
Guillaume SpielmannSchool of Kinesiology, College of Human Sciences & Education, Louisiana State University, Baton Rouge, LA 70802, USA.
Justin C BrownPennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA; LSU Health Sciences Center, New Orleans School of Public Health, Louisiana Tumor Registry, 2020 Gravier St., New Orleans, LA 70112, USA; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, 533 Bolivar St., New Orleans, LA 70112, USA; Louisiana Cancer Research Center, 1700 Tulane Ave., New Orleans, LA 70112, USA. Electronic address: Justin.Brown@pbrc.edu.

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Eric Ravussin · 2005 to 2026
$26.5M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Training in Botanical Approaches to Combat Metabolic SyndromeT32AT004094 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BRANTLEY, PHILLIP J, STEPHENS, JACQUELINE M · 2009 to 2024
$5.7M
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon CancerU01CA271279 · NCI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Justin C Brown, JEFFREY A MEYERHARDT · 2022 to 2026
$4.9M
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colon CancerR01CA270274 · NCI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Justin C Brown · 2022 to 2026
$3.2M
Inflammation, Physical Activity, and Colon Cancer Recurrence and SurvivalR00CA218603 · NCI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BROWN, JUSTIN C · 2019 to 2021
$747k
CANCAN - PENNINGTONOT2CA278684 · NCI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI HEYMSFIELD, STEVEN · 2022 to 2025
$457k
NCCIH NIH HHS T32 AT004094NCI NIH HHS OT2 CA278684NCI NIH HHS R00 CA218603NCI NIH HHS R01 CA270274NCI NIH HHS U01 CA271279NIDDK NIH HHS P30 DK072476NIDDK NIH HHS P30 DK127984
6 · The paper itself

Abstract

backgroundPhysical activity is associated with improved disease-free survival in colorectal cancer survivors. This report describes the purpose, design, recruitment, and exercise adherence results of the National Cancer Institute (NCI)-sponsored Exercise and Colorectal Cancer Treatment (EXACT) trial.

methodsThe primary objective of the EXACT trial is to determine if randomization to 150 min per week of moderate-intensity aerobic exercise reduces systemic inflammation among stage I-III colorectal cancer survivors compared with a waitlist control group over 12 weeks. Participants were provided with an in-home treadmill and heart rate monitor. Characteristics associated with randomization were identified using χ

resultsBetween August 2019 and February 2023, 3082 colorectal cancer survivors were invited to participate, 89 were screened, and 60 were randomized to the study protocol. Younger age (P = 0.02), female sex (P = 0.002), white race (P = 0.01), proximal time since tumor resection (P = 0.02), and regional tumor stage (P < 0.001) were associated with study participation. Average exercise adherence was 92.2 % (95 % CI: 85.5, 98.8) and all study participants achieved ≥80 % exercise adherence. Endpoint data collection was completed for all participants in May 2023.

conclusionThe results from the EXACT trial will characterize the changes that occur from exercise to advance our understanding of the biological mechanisms by which exercise may prevent tumor recurrence and death in colorectal cancer survivors.

Indexed as

Colorectal NeoplasmsExerciseAgedAge FactorsCancer SurvivorsDisease-Free SurvivalExercise TherapyFemaleHumansMaleMiddle AgedNeoplasm StagingPatient CompliancePatient SelectionRandomized Controlled Trials as TopicResearch DesignColorectal cancerInflammationInsulin resistancePhysical activitySurvivorship

Identifiers

PMID39362405
PMCPMC11531371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.