Evidence map›Paper›PMID 39362385›Full record

ArticleNeurotoxicology and teratology

Oxidative stress as a potential mechanism linking gestational phthalates exposure to cognitive development in infancy.

Kaegan E Ortlund, Susan L Schantz, Andréa Aguiar, Francheska M Merced-Nieves, Megan L Woodbury, Dana E Goin, Antonia M Calafat, Ginger L Milne, Stephanie M Eick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaegan E OrtlundDepartment of Environmental Sciences, College of Arts and Sciences, Emory University, Atlanta, GA, USA.
Susan L SchantzBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Champaign, IL, USA; Department of Comparative Biosciences, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Andréa AguiarBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Champaign, IL, USA; Department of Comparative Biosciences, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Francheska M Merced-NievesDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Megan L WoodburyDepartment of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA.
Dana E GoinDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Antonia M CalafatDivision of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Ginger L MilneDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Stephanie M EickGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address: stephanie.marie.eick@emory.edu.

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Andrea Aguiar, Susan L Schantz · 2018 to 2026
$18.6M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUG3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHANTZ, SUSAN L · 2016 to 2024
$7.2M
NIEHS NIH HHS P30 ES019776NIH HHS U2C OD023375NIH HHS UG3 OD023272NIH HHS UH3 OD023272
6 · The paper itself

Abstract

backgroundGestational exposure to phthalates, endocrine disrupting chemicals widely used in consumer products, has been associated with poor recognition memory in infancy. Oxidative stress may represent one pathway linking this association. Hence, we examined whether exposure to phthalates was associated with elevated oxidative stress during pregnancy, and whether oxidative stress mediates the relationship between phthalate exposure and recognition memory.

methodsOur analysis included a subset of mother-child pairs enrolled in the Illinois Kids Development Study (IKIDS, N = 225, recruitment years 2013-2018). Concentrations of 12 phthalate metabolites were quantified in 2nd trimester urine samples. Four oxidative stress biomarkers (8-isoprostane-PGF

resultsThe average maternal age at delivery was 31 years and approximately 50 % of participants had a graduate degree. A natural log unit increase in ΣAA, ΣDINP, and ΣDEHP was associated with a statistically significant increase in 8-isoPGF

conclusionsGestational exposure to some phthalates is positively associated with oxidative stress biomarkers, highlighting one mechanistic pathway through which these chemicals may impair early cognitive development.

Indexed as

Child DevelopmentOxidative StressPhthalic AcidsPrenatal Exposure Delayed EffectsAdultBiomarkersCognitionEndocrine DisruptorsFemaleHumansInfantMaleMaternal ExposurePregnancyRecognition, PsychologyBiomarkersEndocrine Disruptorsphthalic acidPhthalic AcidsCognitionInfancyIsoprostanesoxidative stressPhthalatesPregnancy

Identifiers

PMID39362385
PMCPMC11646183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.