ArticleDevelopmental cell2024
Evolution of a large periplasmic disk in Campylobacterota flagella enables both efficient motility and autoagglutination.
Article in Developmental cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Molecular basis of high-torque transmission of the Vibrio polar flagellar motor.Protein & cell · 2026Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural insights into the assembly and evolution of a complex bacterial flagellar motor.Nature microbiology · 2026Article
- The ancient E-ring in bacterial flagellar motors.FEMS microbiology reviews · 2026Review
- Impact of flagellar filament length onJournal of bacteriology · 2025Article
- Species-specific surface dwell times and accumulation of microbes investigated by holographic microscopy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque.Nature microbiology · 2025Article
- Understanding bovine genital campylobacteriosis: A comprehensive review of its threat to global cattle reproduction.Open veterinary journal · 2025Review
- Novel M23 peptidases Pgp4, Pgp5, and Pgp6 contribute to helical cell shape inFrontiers in microbiology · 2025Article
- Molecular model of a bacterial flagellar motorbioRxiv : the preprint server for biology · 2024Article
- Overview of the bacterial/archaeal supermolecular assembly session at the 21st IUPAB and the 62nd Biophysics Society of Japan joint congress.Biophysical reviews · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The flagellar motors of Campylobacter jejuni (C. jejuni) and related Campylobacterota (previously epsilonproteobacteria) feature 100-nm-wide periplasmic "basal disks" that have been implicated in scaffolding a wider ring of additional motor proteins to increase torque, but the size of these disks is excessive for a role solely in scaffolding motor proteins. Here, we show that the basal disk is a flange that braces the flagellar motor during disentanglement of its flagellar filament from interactions with the cell body and other filaments. We show that motor output is unaffected when we shrink or displace the basal disk, and suppressor mutations of debilitated motors occur in flagellar-filament or cell-surface glycosylation pathways, thus sidestepping the need for a flange to overcome the interactions between two flagellar filaments and between flagellar filaments and the cell body. Our results identify unanticipated co-dependencies in the evolution of flagellar motor structure and cell-surface properties in the Campylobacterota.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.