Evidence map›Paper›PMID 39361938›Full record

ArticleJournal of medicinal chemistry2024

Addressing the Intracellular Vestibule of the Plasmodial Lactate Transporter PfFNT by p-Substituted Inhibitors Amplifies In Vitro Activity.

Cornelius Nerlich, Finn Tiedjens, Robin Hertel, Björn Henke, Susan Häuer, Lea S Panitzsch, Kerrin Hansen, Ole Franck, Antonio Mete, Didier Leroy and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cornelius NerlichDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.
Finn TiedjensDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.
Robin HertelDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.
Björn HenkeDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.
Susan HäuerDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.
Lea S PanitzschBernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany.
Kerrin HansenIntana Bioscience GmbH, Lochhamer Str. 29a, 82152 Planegg, Germany.
Ole FranckDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.
Antonio MeteMedsyndesign Ltd, ATIC, 5 Oakwood Drive, LE11 3QF Loughborough, U.K.
Didier LeroyR&D Department/Drug Discovery, ICC, Medicines for Malaria Venture (MMV), 20 Route de Pré Bois, 1215 Geneva 15, Switzerland.
Dennis SchadeDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.ORCID 0000-0002-5515-1821
Christian PeiferDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.ORCID 0000-0003-1532-7826
Stefan HannusIntana Bioscience GmbH, Lochhamer Str. 29a, 82152 Planegg, Germany.
Frank BeckerIntana Bioscience GmbH, Lochhamer Str. 29a, 82152 Planegg, Germany.
Sergio WittlinSwiss Tropical and Public Health Institute, Kreuzstr. 2, 4123 Allschwil, Switzerland.ORCID 0000-0002-0811-0912
Tobias SpielmannBernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany.
Eric BeitzDepartment of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.ORCID 0000-0001-5912-6626

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibition of the lactate transporter PfFNT is a valid novel mode of action against malaria parasites. Current pyridine-substituted pentafluoro-3-hydroxy-pent-2-en-1-ones act as substrate analogs with submicromolar EC

Indexed as

AntimalarialsPlasmodium falciparumAlkenesAnimalsHumansMalariaMiceMolecular Docking SimulationMonocarboxylic Acid TransportersProtozoan ProteinsPyridinesStructure-Activity RelationshipAlkenesAntimalarialsMonocarboxylic Acid TransportersProtozoan ProteinsPyridines

Identifiers

PMID39361938
PMCPMC11513924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.