ArticleScience (New York, N.Y.)2024
A multivalent mRNA-LNP vaccine protects against
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- Using a mental model approach to undercut the effects of exposure to mRNA vaccination misconceptions: Two randomized trials.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Microbiome-based therapeutics forGut microbes · 2026Review
- Bioengineering strategies for improving the immunogenicity of mRNA vaccines.Signal transduction and targeted therapy · 2026Review
- Early-life colonization withScience (New York, N.Y.) · 2026Article
- The impact of TcdB conformational dynamics on vaccination against Clostridioides difficile.PLoS pathogens · 2026Article
- Polystyrene microplastics facilitateApplied and environmental microbiology · 2026Article
- KRAS signaling networks, mutational heterogeneity, and emerging therapeutic strategies for cancer treatment.Biomarker research · 2026Review
- An mRNA-Lipid Nanoparticle Platform Encoding the Conserved Outer Membrane Protein BamA Elicits Broadly Cross-Reactive Systemic and Mucosal Antibodies Against Antimicrobial-ResistantbioRxiv : the preprint server for biology · 2026Article
- Design and Synthesis of Phosphonoproline-Proline Bioisosteric Mimetics of Proline Dimers: Pseudopeptide Constructs as Potential Inhibitors of the Zn-Metalloprotease PPEP‑1 Associated withACS medicinal chemistry letters · 2026Article
- Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function.bioRxiv : the preprint server for biology · 2026Article
- Article
- Empowering global disease surveillance with CURED: a tool for rapid identification of unique genomic biomarkers.mSystems · 2026Article
- Article
- Trivalent multi-epitope mRNA vaccine against norovirus, rotavirus, and adenovirus 40/41: epitope screening, molecular docking, and molecular dynamics simulation with in silico validation guided by immunoinformatics.Infectious diseases of poverty · 2026Article
- Single intramuscular injection of self-amplifying RNA ofScience (New York, N.Y.) · 2026Article
- Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026Review
- Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4bioRxiv : the preprint server for biology · 2026Article
- mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 in animal models.Journal of virology · 2026Article
- Review
- Article
Corrections and comments
- Commented on by
Authors and funding
29 authors.
Mohamad-Gabriel Alameh *Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5672-6930
Alexa Semon *Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0551-1446
Nile U BayardDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yi-Gen PanDivision of Infectious Disease, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2427-2759
Garima DwivediDivision of Infectious Disease, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James KnoxDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3523-0661
Rochelle C GloverDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-5699-0184
Paula C RangelDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ceylan TanesDivision of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3472-5934
Qianxuan SheDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Haitao HuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0002-6964-2314
Srinivasa Reddy BonamDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0002-2888-2418
Jeffrey R MaslankaInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6982-5946
Paul J PlanetThe Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-0543-0539
Ahmed M MoustafaDivision of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-9949-6936
Benjamin DavisDivision of Infectious Disease, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4048-7653
Anik ChevrierChemical Engineering Department, Polytechnique Montreal, Montreal, QC, Canada.ORCID 0000-0002-3664-8146
Mitchell BeattieAcuitas Therapeutics, Vancouver, British Columbia, Canada.ORCID 0000-0001-8391-4809
Houping NiAcuitas Therapeutics, Vancouver, British Columbia, Canada.
Gabrielle BlizardDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Emma E FurthDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-7645-2869
Marc LavertuChemical Engineering Department, Polytechnique Montreal, Montreal, QC, Canada.ORCID 0000-0002-2750-3607
Mark A SellmyerDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1407-1905
Ying TamAcuitas Therapeutics, Vancouver, British Columbia, Canada.ORCID 0000-0002-4083-5251
Michael C AbtInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-7351-2061
Drew WeissmanPenn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1501-6510
Joseph P ZackularDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3228-3055
Funding
Project 3: Defining adaptive immune interactions that shape Clostridioides difficile infectionU19AI174998 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, DREW WEISSMAN · 2023 to 2026
$7.6MInvestigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantationR01AI158830 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ABT, MICHAEL C. · 2021 to 2025
$2.4MNIAID NIH HHS R01 AI158830NIAID NIH HHS U19 AI174998
Abstract
PubMed holds no abstract for this paper.
Indexed as
Bacterial ToxinsBacterial VaccinesClostridioides difficileClostridium InfectionsmRNA VaccinesNanoparticlesVaccines, CombinedAnimalsBacterial ProteinsDisease Models, AnimalFemaleGastrointestinal MicrobiomeImmunity, CellularImmunity, HumoralLiposomesMiceBacterial ProteinsBacterial ToxinsBacterial VaccinesLipid NanoparticlesLiposomesmRNA VaccinesRNA, MessengerVaccines, CombinedVirulence Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.