ArticleAmerican journal of physiology. Renal physiology2024
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury.
Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Jussara M do CarmoDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0003-0471-0512
John E HallDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Luzia N S FurukawaLaboratory of Renal Pathophysiology, Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-0457-6651
Viktoria WoronikLaboratory of Renal Pathophysiology, Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Xuemei DaiDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Emily LadnierDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Zhen WangDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0002-8028-8942
Ana C M OmotoDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0003-1062-7109
Alan MoutonDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0001-5973-3071
Xuan LiDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0001-5781-1662
Emilio M Luna-SuarezDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Alexandre A da SilvaDepartment of Physiology and Biophysics, Cardiorenal and Metabolic Diseases Research Center, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0003-4504-0607
Funding
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2013 to 2022
$23.4M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Cardiac protective mechanisms of melanocortin system activationR01HL163076 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jussara M. Do Carmo, Alexandre Alves da Silva · 2023 to 2026
$2.3M
Long-term consequences of parental obesity on developmental programming of cardiorenal diseases in offspringR01DK121411 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI DO CARMO, JUSSARA M. · 2019 to 2021
In the present study, we examined whether chronic intracerebroventricular (ICV) leptin administration protects against ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Twelve-week-old male rats were implanted with an ICV cannula into the right lateral ventricle, and 8-10 days after surgery, leptin (0.021 µg/h,
Indexed as
Acute Kidney InjuryKidneyLeptinReperfusion InjuryAnimalsDisease Models, AnimalEatingGlomerular Filtration RateInfusions, IntraventricularInjections, IntraventricularMaleRatsRats, Sprague-DawleyLeptinCNSglomerular filtration rateinflammationmarkers of kidney injurymarkers of renal injury
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury. · full record | OpenQuestion