ArticlePlant physiology2024
Calcium-dependent protein kinases 5 and 13 enhance salt tolerance in rice by directly activating OsMPK3/6 kinases.
Article in Plant physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The ZmRACK1-ZmCDPK7-ZmAPX1 module regulates plant antiviral immunity.Journal of integrative plant biology · 2026Article
- Cyclic nucleotide-gated channels 14, 15, and 16 coordinate multiple signaling pathways to promote salt tolerance in rice.The Plant journal : for cell and molecular biology · 2026Article
- Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation.Journal of integrative plant biology · 2026Review
- MAPK regulates secondary metabolism and abiotic stress in horticultural and medicinal plants.Horticulture research · 2026Article
- Calcium-Dependent Protein Kinases in Plants: Structure, Signaling, and Multifaceted Regulatory Roles in Development and Stress Adaptation.International journal of molecular sciences · 2026Review
- Oil body membrane proteins as sensors of salt stress in sunflower seedlings: a proteomic insight.Plant signaling & behavior · 2025Article
- Functional analysis of StMAPK19 gene in response to salt stress in potato (Solanum tuberosum L.).BMC plant biology · 2025Article
- Loss of calcium-dependent protein kinases OsCPK5 and OsCPK13 leads to NLR-dependent resistance in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Classification of Calcium-Dependent Protein Kinases and Their Transcriptional Response to Abiotic Stresses in HalophytePlants (Basel, Switzerland) · 2025Article
- ONAC005 enhances salt stress tolerance by promoting suberin deposition in root endodermis.The Plant journal : for cell and molecular biology · 2025Article
- Glycolysis and signal transduction participate in Lycium barbarum in response to NaCl stress through protein phosphorylation.BMC plant biology · 2025Article
- Calcium-dependent protein kinases as central hubs in plant abiotic stress signaling: mechanisms and prospects for crop improvement.Frontiers in plant science · 2025Review
- Calcium-dependent protein kinases in plant immunity: from calcium signaling to network integration.Frontiers in plant science · 2025Review
- Integrated physiological and transcriptomic analyses elucidate the molecular mechanisms of exogenous melatonin-mediated salt tolerance in pomegranate (Frontiers in plant science · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Mitogen-activated protein kinases (MAPKs/MPKs) are pivotal regulators in many stress-signaling pathways in plants. The dual phosphorylation of the TXY motif by MAP kinase kinases (MKKs) is essential for activating MAPKs. Here, we reveal a mechanism for MAPK activation that bypasses the need for MKKs. We identified rice (Oryza sativa) calcium-dependent protein kinase 5 (OsCPK5) and OsCPK13 as positive regulators in salt stress tolerance. These kinases are essential for the full activation of OsMPK3 and OsMPK6 in response to elevated sodium levels, with both OsMPK3 and OsMPK6 also acting as positive regulators in rice salt tolerance. Biochemical analysis demonstrated that OsCPK5/13 directly interact with and activate OsMPK3/6 by phosphorylating the TXY motif in vitro and in vivo. Additionally, we have discovered that OsCPK5/13 relocate from the cell membrane to the nucleus in response to salt stress. This process relies on their N-terminal myristoylation and a calcium-dependent phosphorylation event within the N-terminus. Our results elucidate a MAPK activation pathway in rice that is independent of traditional MKK-mediated phosphorylation, highlighting the crucial roles of OsCPK5 and OsCPK13 in directly phosphorylating and activating OsMPK3/6, which are important for rice tolerance to salt stress.
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