Evidence map›Paper›PMID 39361642›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Memory effects of transcription regulator-DNA interactions in bacteria.

Won Jung, Tai-Yen Chen, Ace George Santiago, Peng Chen

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Won JungDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Tai-Yen ChenDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-2881-3068
Ace George SantiagoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-2280-6297
Peng ChenDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-8582-7661

Funding

Unusual mechanisms of metal regulation in bacteria: from single molecules to single cells to cell communitiesR01GM109993 · NIGMS · CORNELL UNIVERSITY · PI Peng Chen · 2014 to 2026
$3.9M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM109993NIGMS NIH HHS R01 GM109993
6 · The paper itself

Abstract

Memory effect refers to the phenomenon where past events influence a system's current and future states or behaviors. In biology, memory effects often arise from intra- or intermolecular interactions, leading to temporally correlated behaviors. Single-molecule studies have shown that enzymes and DNA-binding proteins can exhibit time-correlated behaviors of their activity. While memory effects are well documented and studied in vitro, no such examples exist in cells to our knowledge. Combining single-molecule tracking (SMT) and single-cell protein quantitation, we find in living

Indexed as

DNA, BacterialEscherichia coliEscherichia coli ProteinsBinding SitesDNA-Binding ProteinsGene Expression Regulation, BacterialProtein BindingTranscription FactorsDNA, BacterialDNA-Binding ProteinsEscherichia coli ProteinsTranscription Factorsgene regulationmemory effects in protein−DNA interactionsMerR- and Fur-family regulatorsmicrodomains in cellssingle-molecule live-cell imaging

Identifiers

PMID39361642
PMCPMC11474097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.