ArticleJournal of applied clinical medical physics2025
Dosimetric impact of variable air cavity within PTV for rectum cancer.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Determining optimal GTV-to-PGTV margins for CT-guided dose-escalated radiotherapy with daily image guidance in locally advanced rectal cancer.Journal of applied clinical medical physics · 2026Article
- Dosimetric impact of variable air cavity within PTV for rectum cancer.Journal of applied clinical medical physics · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to determine the impact of rectal air volume changes on treatment plan quality, and subsequently inform daily cone-beam computed tomography (CBCT) evaluation constraints, in terms of acceptable rectal air volume during treatment.
methodsTwelve rectal cancer patients who exhibited rectal air within the PTV on their planning CT were selected. A study was conducted to evaluate the deterioration in plan quality due to expanding air volume. For each case, the air cavity volume was isotropically expanded in three dimensions using predefined margins of 3, 5, 7, and 10 mm, while deforming bladder and rectum contours. A constraint was applied to the bony anatomy to restrict the deformation. Treatment plans were then generated for all twelve patients by recalculating the reference plan with the expanded air cavity volume.
resultsAs the air cavity expanded, the maximum relative change in D98% coverage, compared to the reference plan, decreased by 10.8% ± 3.5%, while the D2% increased by 3.5% ± 0.9%. The positioning of the air cavity notably influenced the D98% variability with the 3 mm expansion. D98% coverage falls below 95% when the air cavity volume exceeds 17 cm
conclusionAir cavity volumes above 17 cm
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