ArticleeLife2024
Novel risk loci for COVID-19 hospitalization among admixed American populations.
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In one paragraph
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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Who cites it
3 citing papers in PubMed.
- Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.Genetics and molecular biology · 2026Article
- Polygenic risk of idiopathic pulmonary fibrosis and COVID-19 severity.ERJ open research · 2025Article
- Genetic patterns related to von Willebrand factor: implications on the need for mechanical ventilation, severity, and death in COVID-19.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
122 authors.
Silvia Diz-de Almeida *ERN-ITHACA-European Reference Network, Soria, Spain.ORCID https://orcid.org/0000-0003-2813-8928
Raquel Cruz *ERN-ITHACA-European Reference Network, Soria, Spain.
Andre D LuchessiUniversidade Federal do Rio Grande do Norte, Departamento de Analises Clinicas e Toxicologicas, Natal, Brazil.
José M Lorenzo-SalazarGenomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.
Miguel López de HerediaCIBERER, ISCIII, Madrid, Spain.
Inés QuintelaFundación Pública Galega de Medicina Xenómica, Sistema Galego de Saúde (SERGAS), Santiago de Compostela, Spain.
Rafaela González-MontelongoGenomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.
Vivian Nogueira SilbigerUniversidade Federal do Rio Grande do Norte, Departamento de Analises Clinicas e Toxicologicas, Natal, Brazil.ORCID https://orcid.org/0000-0002-9252-0278
Marta Sevilla PorrasCIBERER, ISCIII, Madrid, Spain.
Jair Antonio Tenorio CastañoERN-ITHACA-European Reference Network, Soria, Spain.
Julian NevadoERN-ITHACA-European Reference Network, Soria, Spain.
Jose María AguadoUnit of Infectious Diseases, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Carlos AguilarHospital General Santa Bárbara de Soria, Soria, Spain.
Sergio Aguilera-AlbesaPediatric Neurology Unit, Department of Pediatrics, Navarra Health Service Hospital, Pamplona, Spain.
Virginia AlmadanaHospital Universitario Virgen Macarena, Neumología, Sevilla, Spain.
Berta AlmogueraCIBERER, ISCIII, Madrid, Spain.
Nuria AlvarezSpanish National Cancer Research Centre, Human Genotyping-CEGEN Unit, Madrid, Spain.
Álvaro Andreu-BernabeuDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain.
Eunate Arana-ArriBiocruces Bizkai HRI, Bizkaia, Spain.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain.
María J ArranzFundació Docència I Recerca Mutua Terrassa, Barcelona, Spain.
Maria-Jesus ArtigaSpanish National Cancer Research Centre, CNIO Biobank, Madrid, Spain.
Raúl C Baptista-RosasHospital General de Occidente, Zapopan Jalisco, Mexico.ORCID https://orcid.org/0000-0002-0273-4740
María Barreda-SánchezUniversidad Católica San Antonio de Murcia (UCAM), Murcia, Spain.
Moncef Belhassen-GarciaHospital Universitario de Salamanca-IBSAL, Servicio de Medicina Interna-Unidad de Enfermedades Infecciosas, Salamanca, Spain.
Joao F BezerraEscola Tecnica de Saúde, Laboratorio de Vigilancia Molecular Aplicada, Brasilia, Brazil.
Marcos A C BezerraFederal University of Pernambuco, Genetics Postgraduate Program, Recife, Brazil.
Lucía Boix-PalopHospital Universitario Mutua Terrassa, Barcelona, Spain.
María BrionInstituto de Investigación Sanitaria de Santiago (IDIS), Xenética Cardiovascular, Santiago de Compostela, Spain.
Ramón BrugadaCIBERCV, ISCIII, Madrid, Spain.
Matilde BustosInstitute of Biomedicine of Seville (IBiS), Consejo Superior de Investigaciones Científicas (CSIC)- University of Seville- Virgen del Rocio University Hospital, Seville, Spain.
Enrique J CalderónInstitute of Biomedicine of Seville (IBiS), Consejo Superior de Investigaciones Científicas (CSIC)- University of Seville- Virgen del Rocio University Hospital, Seville, Spain.
Cristina CarbonellHospital Universitario de Salamanca-IBSAL, Servicio de Medicina Interna, Salamanca, Spain.
Luis CastanoCIBERER, ISCIII, Madrid, Spain.
Jose E CastelaoOncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur, Xerencia de Xestion Integrada de Vigo-Servizo Galego de Saúde, Vigo, Spain.
Rosa Conde-VicenteHospital Universitario Río Hortega, Valladolid, Spain.
M Lourdes Cordero-LorenzanaServicio de Medicina intensiva, Complejo Hospitalario Universitario de A Coruña (CHUAC), Sistema Galego de Saúde (SERGAS), A Coruña, Spain.
Jose L Cortes-SanchezTecnológico de Monterrey, Monterrey, Mexico.
Marta CortonCIBERER, ISCIII, Madrid, Spain.
M Teresa DarnaudeHospital Universitario Mostoles, Unidad de Genética, Madrid, Spain.
Alba De Martino-RodríguezInstituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain.ORCID https://orcid.org/0000-0002-2436-9852
Victor Del Campo-PérezPreventive Medicine Department, Instituto de Investigacion Sanitaria Galicia Sur, Xerencia de Xestion Integrada de Vigo-Servizo Galego de Saúde, Vigo, Spain.
Aranzazu Diaz de BustamanteHospital Universitario Mostoles, Unidad de Genética, Madrid, Spain.
Elena Domínguez-GarridoUnidad Diagnóstico Molecular, Fundación Rioja Salud, La Rioja, Spain.
Rocío EirósHospital Universitario de Salamanca-IBSAL, Servicio de Cardiología, Salamanca, Spain.
María Carmen FariñasIDIVAL, Cantabria, Spain.
María J Fernandez-NestosaUniversidad Nacional de Asunción, Facultad de Politécnica, Paraguay, United States.ORCID https://orcid.org/0000-0001-7764-7791
Uxía Fernández-RobeloUrgencias Hospitalarias, Complejo Hospitalario Universitario de A Coruña (CHUAC), Sistema Galego de Saúde (SERGAS), A Coruña, Spain.
Amanda Fernández-RodríguezCIBERINFEC, ISCIII, Madrid, Spain.
Tania Fernández-VillaCIBERESP, ISCIII, Madrid, Spain.
Manuela Gago-DominguezFundación Pública Galega de Medicina Xenómica, Sistema Galego de Saúde (SERGAS), Santiago de Compostela, Spain.
Belén Gil-FournierHospital Universitario de Getafe, Servicio de Genética, Madrid, Spain.
Javier Gómez-ArrueInstituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain.
Beatriz González ÁlvarezInstituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain.
Fernan Gonzalez Bernaldo de QuirósMinisterio de Salud Ciudad de Buenos Aires, Buenos Aires, Argentina.
Anna González-NeiraSpanish National Cancer Research Centre, Human Genotyping-CEGEN Unit, Madrid, Spain.
Javier González-PeñasDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain.
Juan F Gutiérrez-BautistaHospital Universitario Virgen de las Nieves, Servicio de Análisis Clínicos e Inmunología, Granada, Spain.
María José HerreroIIS La Fe, Plataforma de Farmacogenética, Valencia, Spain.
Antonio Herrero-GonzalezData Analysis Department, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.
María A Jimenez-SousaCIBERINFEC, ISCIII, Madrid, Spain.
María Claudia LattigUniversidad de los Andes, Facultad de Ciencias, Bogotá, Colombia.ORCID https://orcid.org/0000-0003-2113-9266
Anabel Liger BorjaHospital General de Segovia, Medicina Intensiva, Segovia, Spain.
Rosario Lopez-RodriguezCIBERER, ISCIII, Madrid, Spain.
Esther ManceboHospital Universitario 12 de Octubre, Department of Immunology, Madrid, Spain.
Caridad Martín-LópezHospital General de Segovia, Medicina Intensiva, Segovia, Spain.
Vicente MartínCIBERESP, ISCIII, Madrid, Spain.
Oscar Martinez-NietoSIGEN Alianza Universidad de los Andes - Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Iciar Martinez-LopezUnidad de Genética y Genómica Islas Baleares, Islas Baleares, Spain.
Michel F Martinez-ResendezTecnológico de Monterrey, Monterrey, Mexico.
Angel Martinez-PerezGenomics of Complex Diseases Unit, Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain.ORCID https://orcid.org/0000-0002-5934-1454
Juliana F MazzeuUniversidade de Brasília, Faculdade de Medicina, Brasília, Brazil.
Eleuterio Merayo MacíasHospital El Bierzo, Unidad Cuidados Intensivos, León, Spain.
Pablo MinguezCIBERER, ISCIII, Madrid, Spain.
Victor Moreno CuerdaHospital Universitario Mostoles, Medicina Interna, Madrid, Spai, Spain.
Silviene F OliveiraPrograma de Pós-Graduação em Ciencias da Saude (UnB), Brazila, Brazil.ORCID https://orcid.org/0000-0002-7741-0257
Eva Ortega-PainoSpanish National Cancer Research Centre, CNIO Biobank, Madrid, Spain.
Mara ParelladaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain.
Estela Paz-ArtalHospital Universitario 12 de Octubre, Department of Immunology, Madrid, Spain.
Ney P C SantosUniversidade Federal do Pará, Núcleo de Pesquisas em Oncologia, Belém, Brazil.
Patricia Pérez-MatuteInfectious Diseases, Microbiota and Metabolism Unit, CSIC Associated Unit, Center for Biomedical Research of La Rioja (CIBIR), Logroño, Spain.
Patricia PerezInditex, A Coruña, Corunna, Spain.
M Elena Pérez-TomásInstituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain.ORCID https://orcid.org/0000-0002-5429-3414
Teresa PeruchoGENYCA, Madrid, Spain.
Mellina Pinsach-AbuinCIBERCV, ISCIII, Madrid, Spain.
Guillermo PitaSpanish National Cancer Research Centre, Human Genotyping-CEGEN Unit, Madrid, Spain.
Ericka N Pompa-MeraInstituto Mexicano del Seguro Social (IMSS), Centro Médico Nacional Siglo XXI, Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Mexico City, Mexico.
Gloria L Porras-HurtadoClinica Comfamiliar Risaralda, Pereira, Colombia.
Aurora PujolCIBERER, ISCIII, Madrid, Spain.ORCID https://orcid.org/0000-0002-9606-0600
Soraya Ramiro LeónHospital Universitario de Getafe, Servicio de Genética, Madrid, Spain.
Salvador ResinoCIBERINFEC, ISCIII, Madrid, Spain.
Marianne R FernandesUniversidade Federal do Pará, Núcleo de Pesquisas em Oncologia, Belém, Brazil.
Emilio Rodríguez-RuizIDIS, Seongnam, Republic of Korea.
Fernando Rodriguez-ArtalejoCIBERESP, ISCIII, Madrid, Spain.
José A Rodriguez-GarciaComplejo Asistencial Universitario de León, León, Spain.
Francisco Ruiz-CabelloIDIS, Seongnam, Republic of Korea.
Javier Ruiz-HornillosHospital Infanta Elena, Allergy Unit, Valdemoro, Madrid, Spain.
Pablo RyanCIBERINFEC, ISCIII, Madrid, Spain.ORCID https://orcid.org/0000-0002-4212-7419
José Manuel SoriaGenomics of Complex Diseases Unit, Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain.
Juan Carlos SoutoHaemostasis and Thrombosis Unit, Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain.
Eduardo TamayoHospital Clinico Universitario de Valladolid, Servicio de Anestesiologia y Reanimación, Valladolid, Spain.
Alvaro Tamayo-VelascoHospital Clinico Universitario de Valladolid, Servicio de Hematologia y Hemoterapia, Valladolid, Spain.
Juan Carlos Taracido-FernandezData Analysis Department, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital - Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.
Alejandro TeperHospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina.
Lilian Torres-TobarFundación Universitaria de Ciencias de la Salud, Bogotá, Colombia.
Miguel UriosteSpanish National Cancer Research Centre, Familial Cancer Clinical Unit, Madrid, Spain.
Juan Valencia-RamosUniversity Hospital of Burgos, Burgos, Spain.
Zuleima YáñezUniversidad Simón Bolívar, Facultad de Ciencias de la Salud, Barranquilla, Colombia.
Ruth ZarateCentro para el Desarrollo de la Investigación Científica, Asunción, Paraguay.
Itziar de RojasCentre for Biomedical Network Research on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Agustín RuizCentre for Biomedical Network Research on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Pascual SánchezCIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
Luis Miguel RealHospital Universitario de Valme, Unidad Clínica de Enfermedades Infecciosas y Microbiología, Sevilla, Spain.ORCID https://orcid.org/0000-0003-4932-7429
SCOURGE Cohort Group
Encarna Guillen-NavarroInstituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain.
Carmen AyusoCIBERER, ISCIII, Madrid, Spain.
Esteban ParraDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, Canada.ORCID https://orcid.org/0000-0002-2057-8577
José A RianchoCIBERER, ISCIII, Madrid, Spain.ORCID https://orcid.org/0000-0003-0691-8755
Augusto Rojas-MartinezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico.ORCID https://orcid.org/0000-0003-3765-6778
Carlos FloresGenomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.ORCID https://orcid.org/0000-0001-5352-069X
Pablo LapunzinaERN-ITHACA-European Reference Network, Soria, Spain.
Ángel CarracedoCIBERER, ISCIII, Madrid, Spain.ORCID https://orcid.org/0000-0003-1085-8986
Funding
Agencia Estatal de Investigación RTC-2017-6471-1Cabildo Insular de Tenerife CGIEU0000219140European Regional Development Fund A way of making EuropeFundación Canaria Instituto de Investigación Sanitaria de Canarias PIFIISC20/57Instituto de Salud Carlos III COV20_00181Instituto de Salud Carlos III COV20_00622Instituto de Salud Carlos III COV20/00792Instituto de Salud Carlos III COV20_1144Instituto de Salud Carlos III PI20/00876
Abstract
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (
Indexed as
COVID-19Genetic Predisposition to DiseaseGenome-Wide Association StudyHospitalizationAgedFemaleGenetic LociHumansLatin AmericaMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsSARS-CoV-2COVID-19geneticsgenomicsGWASnoneSNP
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