Evidence map›Paper›PMID 39361042›Full record

ArticleInorganic chemistry2024

Bombesin-Targeted Delivery of β-Carboline-Based Ir(III) and Ru(II) Photosensitizers for a Selective Photodynamic Therapy of Prostate Cancer.

Juan Sanz-Villafruela, Cristina Bermejo-Casadesús, Gerard Riesco-Llach, Mònica Iglesias, Marta Martínez-Alonso, Marta Planas, Lidia Feliu, Gustavo Espino, Anna Massaguer

Abstract read
In one paragraph

Article in Inorganic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan Sanz-VillafruelaUniversidad de Burgos, Departamento de Química, Facultad de Ciencias, Plaza Misael Bañuelos s/n, Burgos 09001, Spain.
Cristina Bermejo-CasadesúsUniversitat de Girona, Departament de Biologia, Facultat de Ciències, Maria Aurelia Capmany 40, Girona 17003, Spain.ORCID 0000-0002-3715-8114
Gerard Riesco-LlachLIPPSO, Departament de Química, Facultat de Ciències, Universitat de Girona, Maria Aurelia Capmany 69, Girona 17003, Spain.ORCID 0000-0002-9869-7488
Mònica IglesiasUniversitat de Girona, Departament de Química, Facultat de Ciències, Maria Aurelia Capmany 69, Girona 17003, Spain.
Marta Martínez-AlonsoUniversidad de Burgos, Departamento de Química, Facultad de Ciencias, Plaza Misael Bañuelos s/n, Burgos 09001, Spain.ORCID 0000-0002-0931-5274
Marta PlanasLIPPSO, Departament de Química, Facultat de Ciències, Universitat de Girona, Maria Aurelia Capmany 69, Girona 17003, Spain.ORCID 0000-0003-4988-4970
Lidia FeliuLIPPSO, Departament de Química, Facultat de Ciències, Universitat de Girona, Maria Aurelia Capmany 69, Girona 17003, Spain.ORCID 0000-0001-9792-6106
Gustavo EspinoUniversidad de Burgos, Departamento de Química, Facultad de Ciencias, Plaza Misael Bañuelos s/n, Burgos 09001, Spain.ORCID 0000-0001-5617-5705
Anna MassaguerUniversitat de Girona, Departament de Biologia, Facultat de Ciències, Maria Aurelia Capmany 40, Girona 17003, Spain.ORCID 0000-0003-1312-593X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in Ir(III) and Ru(II) photosensitizers (PSs), their lack of selectivity for cancer cells has hindered their use in photodynamic therapy (PDT). We disclose the synthesis and characterization of two pairs of Ir(III) and Ru(II) polypyridyl complexes bearing two β-carboline ligands (N^N') functionalized with -COOMe (

Indexed as

Antineoplastic AgentsBombesinCarbolinesIridiumPhotochemotherapyPhotosensitizing AgentsProstatic NeoplasmsRutheniumApoptosisCell Line, TumorCell ProliferationCell SurvivalCoordination ComplexesDrug Screening Assays, AntitumorHumansMaleAntineoplastic AgentsBombesinCarbolinesCoordination ComplexesIridiumnorharmanPhotosensitizing AgentsRuthenium

Identifiers

PMID39361042
PMCPMC11483813

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.