Evidence map›Paper›PMID 39360989›Full record

ArticleCardiology journal2024

Endoplasmic reticulum stress and expression of nitric oxide synthases in heart failure with preserved and with reduced ejection fraction - pilot study.

Karol Momot, Małgorzata Wojciechowska, Kamil Krauz, Katarzyna Czarzasta, Liana Puchalska, Maciej Zarębiński, Agnieszka Cudnoch-Jędrzejewska

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Cardiology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Karol MomotDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Poland.ORCID 0000-0001-8659-2948
Małgorzata WojciechowskaDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Poland. malgorzata.wojciechowska2@wum.edu.pl.
Kamil KrauzDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Poland.
Katarzyna CzarzastaDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Poland.
Liana PuchalskaDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Poland.
Maciej ZarębińskiDepartment of Invasive Cardiology, Independent Public Specialist Western Hospital John Paul II Lazarski University, Grodzisk Mazowiecki, Poland.
Agnieszka Cudnoch-JędrzejewskaDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnfolded Protein Response (UPR), endoplasmic reticulum (ER) stress, and inducible nitric oxide synthase (iNOS) overexpression have been found to influence heart failure with preserved ejection fraction (HFpEF) pathogenesis. Their importance in heart failure with reduced ejection fraction (HFrEF) is not entirely established; there is little data involving a detailed comparison between HFpEF and HFrEF from this perspective. This pilot study aimed to compare circulating levels of Glucose-regulated protein 78kDa (GRP78) (ER - stress marker) and all NOS isoforms between both HFpEF and HFrEF and to analyze the correlation between these markers and the clinical characteristics of the patients.

methodsForty-two patients with HFpEF and thirty-eight with HFrEF were involved in this study. Clinical characteristics and echocardiographic data were obtained. Basic laboratory tests were performed and ELISA tests for iNOS, endothelial NOS (eNOS), neuronal NOS (nNOS), and GRP78.

resultsPatients with HFpEF had lower circulating levels of GRP78 and higher iNOS concentrations when compared to HFrEF patients (P = 0.023, P < 0.0001, accordingly). The subgroup of the HFpEF population with eGFR < 60 mL/min/1.73m2 had higher nNOS and eNOS levels than HFpEF patients with normal GFR (P = 0.049, P = 0.035, respectively). In the HFrEF subgroup, patients with coexistent diabetes mellitus had elevated concentrations of nNOS compared to the subpopulation without diabetes mellitus (P = 0.041). There was a positive correlation between eNOS and nNOS concentrations (ρ = 0.86, P < 0.0001).

conclusionsIn HFpEF, there is a more intensified iNOS overexpression, while in HFrEF, ER stress is more prominent.

Indexed as

BiomarkersEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressHeart FailureNitric Oxide Synthase Type IIStroke VolumeAgedEchocardiographyFemaleHeat-Shock ProteinsHumansMaleMiddle AgedNitric Oxide Synthase Type INitric Oxide Synthase Type IIIPilot ProjectsBiomarkersEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanNitric Oxide Synthase Type INitric Oxide Synthase Type IINitric Oxide Synthase Type IIINOS2 protein, humanNOS3 protein, humanendoplasmic reticulum stressheart failure with preserved ejection fractionheart failure with reduced ejection fractionnitrosative stressoxidative stress

Identifiers

PMID39360989
PMCPMC11706269

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