Evidence map›Paper›PMID 39360854›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2024

Perinatal and Neonatal Chikungunya Virus Transmission: A Case Series.

Fátima C P A Di Maio Ferreira, Ana M Bispo de Filippis, Maria Elisabeth L Moreira, Simone B de Campos, Trevon Fuller, Fernanda C R Lopes, Patrícia Brasil

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In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  13. [Mother-to-Child Transmission of Chikungunya Virus and Its Impact on the Neonatal Nervous System].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fátima C P A Di Maio FerreiraFollow-up Clinic, Neonatal Intensive Care Unit, Hospital Universtário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Department of Pediatrics and Neonatology (UNIRIO), Rio de Janeiro, Brazil.ORCID 0000-0002-2540-8665
Ana M Bispo de FilippisLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Maria Elisabeth L MoreiraPesquisa Clínica Aplicada, Instituto Nacional da Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Simone B de CamposFollow-up Clinic, Physiotherapy and Occupational Therapy Clinic, Hospital Universtário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro (UNIRIO, Physiotherapy Departament), Rio de Janeiro, Brazil.
Trevon FullerUCLA Institute for the Enviroment and Sustainability, Los Angeles, CA, USA.ORCID 0000-0001-9954-4267
Fernanda C R LopesDepartament of Radiology, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense (UFF), Rio de Janeiro, Brazil.
Patrícia BrasilLaboratório de Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Funding

Centro Nacional de PesquisaFAPERJ 101137283Fundação Carlos Chagas de Amparo à Pesquisa do Estado do Rio de Janeiro
6 · The paper itself

Abstract

backgroundLarge-scale epidemics in countries with high birth rates can create a concerning scenario where pregnant people are more likely to transmit the virus. In addition, increased international mobility has made arboviruses a growing problem for travelers. The increased risk of vertical transmission has been related to maternal viremia near delivery. Such transmission leads to severe infection of newborns and may be associated with subsequent neurological impairment including cerebral palsy. This case series provides an overview of clinical and laboratory findings in pregnant individuals with confirmed chikungunya virus (CHIKV) infection as well as the clinical effects on their newborn emphasizing the severity of neonatal chikungunya.

methodsAn ambispective case series enrolled newborns with confirmed exposure to CHIKV in utero or in the neonatal period.

resultsDuring the delivery period, the transmission rate among viremic individuals was approximately 62% (18/29). Fever, irritability, rash, and poor feeding in the first week of life were critical signs of neonatal chikungunya, highlighting its severity.

conclusionClose monitoring of healthy newborns during the first week of life is essential in areas affected by CHIKV epidemics, and in offspring of pregnant travelers who visited the outbreaks zones. This case series is intended to increase neonatologists' awareness of the possibility of mother-to-child transmission of CHIKV among newborns with a sepsis-like presentation. Prioritizing CHIKV vaccination for women of childbearing age should also be considered.

Indexed as

Chikungunya FeverInfectious Disease Transmission, VerticalPregnancy Complications, InfectiousAdultChikungunya virusFemaleHumansInfant, NewbornMalePregnancyViremiachikungunyamother-to-childneonatal encephalophatyneonatal sepsisnewbornvertical transmission

Identifiers

PMID39360854
PMCPMC11599154

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.