ArticleClinical and translational medicine2024
Structural inequality and temporal brain dynamics across diverse samples.
Article in Clinical and translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Cross-paradigm fNIRS brain activity in 1-month-old infants across The Gambia and the United Kingdom.Neurophotonics · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Chewing modulates theta oscillation and functional connectivity of the frontocentral cortex in attention and working memory.Scientific reports · 2025Article
- Cardiovascular risk factors and the allostatic interoceptive network in dementia.Cardiovascular research · 2025Article
- Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries.Nature aging · 2025Article
- Creative experiences and brain clocks.Nature communications · 2025Article
- The exposome of healthy and accelerated aging across 40 countries.Nature medicine · 2025Article
- Resilience and brain health in global populations.Nature medicine · 2025Review
- Qualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings.EClinicalMedicine · 2025Article
- Article
- Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas.Nature aging · 2025Article
- Structural inequality and temporal brain dynamics across diverse samples.Clinical and translational medicine · 2024Article
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Authors and funding
36 authors.
Funding
Abstract
backgroundStructural income inequality - the uneven income distribution across regions or countries - could affect brain structure and function, beyond individual differences. However, the impact of structural income inequality on the brain dynamics and the roles of demographics and cognition in these associations remains unexplored.
methodsHere, we assessed the impact of structural income inequality, as measured by the Gini coefficient on multiple EEG metrics, while considering the subject-level effects of demographic (age, sex, education) and cognitive factors. Resting-state EEG signals were collected from a diverse sample (countries = 10; healthy individuals = 1394 from Argentina, Brazil, Colombia, Chile, Cuba, Greece, Ireland, Italy, Turkey and United Kingdom). Complexity (fractal dimension, permutation entropy, Wiener entropy, spectral structure variability), power spectral and aperiodic components (1/f slope, knee, offset), as well as graph-theoretic measures were analysed.
findingsDespite variability in samples, data collection methods, and EEG acquisition parameters, structural inequality systematically predicted electrophysiological brain dynamics, proving to be a more crucial determinant of brain dynamics than individual-level factors. Complexity and aperiodic activity metrics captured better the effects of structural inequality on brain function. Following inequality, age and cognition emerged as the most influential predictors. The overall results provided convergent multimodal metrics of biologic embedding of structural income inequality characterised by less complex signals, increased random asynchronous neural activity, and reduced alpha and beta power, particularly over temporoposterior regions.
conclusionThese findings might challenge conventional neuroscience approaches that tend to overemphasise the influence of individual-level factors, while neglecting structural factors. Results pave the way for neuroscience-informed public policies aimed at tackling structural inequalities in diverse populations.
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