Evidence map›Paper›PMID 39360597›Full record

ArticleJournal of cosmetic dermatology2024

HArmonyCa™ hybrid filler to restore connective tissue: An Italian real-life retrospective study.

Ilaria Proietti, Alessandra Spagnoli, Alison Favaroni, Alessandro Gritti, Marco Dal Canton, Sandro Quartucci, Chantal Sciuto, Dario Bertossi, Mariagrazia Patalano, Maurizio Cavallini and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ilaria ProiettiDepartment of Medical-Surgical Sciences and Biotechnologies, Polo Pontino, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0003-3795-3190
Alessandra SpagnoliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Alison FavaroniScientific Writing, Torgiano (PG), Italy.ORCID https://orcid.org/0000-0003-2099-2951
Alessandro GrittiChirurgia Maxillo Facciale, Milan, Italy.
Marco Dal CantonAmbulatory of Medical and Surgical Dermatology, Belluno, Italy.
Sandro QuartucciPrivate Practice 1, Rome, Italy.
Chantal SciutoPrivate Practice 2, Rome, Italy.
Dario BertossiSection of Oral and Maxillofacial Surgery, Department of Surgical Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-8635-9967
Mariagrazia PatalanoPrivate Practice, Messina, Italy.
Maurizio CavalliniDepartment of Operative Unit, Dermatology and Dermatosurgery, Milan, Italy.
Maria Teresa SalianiPrivate Practice, Modugno (BA), Italy.ORCID https://orcid.org/0000-0001-5870-1764
Nicola KefalasPrivate Practice, Torino, Italy.
Enrica AngelonePrivate Practice, Avezzano (AG), Italy.
Selene MogaveroScientific Writing, Torgiano (PG), Italy.ORCID https://orcid.org/0000-0003-0642-0068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFacial aging and dermal conditions may negatively influence the quality of life, leading patients to seek aesthetic procedures to restore a more satisfying appearance. HArmonyCa™ is a recently developed hybrid filler that combines the actions of the most common dermal fillers, hyaluronic acid (HA) and calcium hydroxylapatite (CaHA).

aimsThis study investigates the efficacy and safety of HArmonyCa™ in patients affected by chrono- and photoaging and several facial skin conditions. PATIENTS/

methodsOne hundred and twenty-nine patients, affected by chrono- and photoaging, and skin conditions such as oily and acne-prone skin, rosacea, or scarring, were treated with HArmonyCa™. Injections followed the retrograde linear fanning technique. A physicians' consensus identified five optimal entry points. The physician and patients assessed treatment outcomes using the Global Aesthetic Improvement Scale (GAIS) 9 months after treatment (including immediate lift effect, skin firmness, and elasticity), and 3D images were taken for documentation. Adverse events (AEs) were evaluated immediately after the procedure and after 9 months.

resultsAccording to the physician's assessments, all patients displayed an improvement in facial appearance, particularly during movement, with the patients' evaluation showing agreement. Only minor AEs were reporte, which resolved spontaneously. Moreover, HArmonyCa™ treatment proved compatible with different medications and aesthetic procedures.

conclusionsThis study shows that one treatment with HArmonyCa™ yields highly satisfactory outcomes in patients affected by skin conditions. For the first time, we show that HArmonyCa™ is a dynamic filler that improves facial laxity during movement. The treatment proved to be safe and fully compatible with other cosmetic procedures and medications.

Indexed as

Cosmetic TechniquesDermal FillersDurapatiteFaceHyaluronic AcidSkin AgingAdultAgedCicatrixConnective TissueEstheticsFemaleHumansItalyMaleMiddle AgedDermal FillersDurapatiteHyaluronic Acidcalcium hydroxylapatiteface rejuvenationHArmonyCa™hyaluronic acidhybrid filler

Identifiers

PMID39360597
PMCPMC11626326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.