Evidence map›Paper›PMID 39360589›Full record

ArticleMacromolecular bioscience2025

Application of Sortase-Mediated Ligation for the Synthesis of Block Copolymers and Protein-Polymer Conjugates.

Johannes Martin, Marcus Michaelis, Saša Petrović, Anne-Catherine Lehnen, Yannic Müllers, Petra Wendler, Heiko M Möller, Matthias Hartlieb, Ulrich Glebe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Johannes MartinInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.
Marcus MichaelisInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.
Saša PetrovićDepartment of Biochemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.
Anne-Catherine LehnenInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.
Yannic MüllersInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.
Petra WendlerDepartment of Biochemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.
Heiko M MöllerInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.
Matthias HartliebInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.
Ulrich GlebeInstitute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam-Golm, Germany.ORCID 0000-0003-0129-7435

Funding

Bundesministerium für Bildung und Forschung 031B0559BBundesministerium für Bildung und Forschung 031B1122BDeutsche Forschungsgemeinschaft (DFG, German Research Foundation) 414977640Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 445804074Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 530253155
6 · The paper itself

Abstract

Sortase-mediated ligation (SML) has become a powerful tool for site-specific protein modification. However, sortase A (SrtA) suffers from low catalytic efficiency and mediates an equilibrium reaction. Therefore, ligations with large macromolecules may be challenging. Here, the synthesis of polymeric building blocks for sortase-mediated ligation constituting peptide-polymers with either the recognition sequence for sortase A (LPX

Indexed as

AminoacyltransferasesBacterial ProteinsCysteine EndopeptidasesPeptidesPolymersCOVID-19PolymerizationSolid-Phase Synthesis TechniquesAminoacyltransferasesBacterial ProteinsCysteine EndopeptidasesPeptidesPolymerssortase Apeptide‐polymer conjugatesprotein‐polymer conjugatesRAFT polymerizationsortase‐mediated ligation

Identifiers

PMID39360589
PMCPMC11727822

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.