Evidence map›Paper›PMID 39360546›Full record

ReviewCurrent drug safety2025

Diuretics-Induced Acute Pancreatitis: Case Series with a Review of the Literature.

Dhruvkumar M Patel, Maitri M Patel, Lalitkumar B Patel, Vahin B Patel, Mukundkumar V Patel, Dhara K Patel

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Current drug safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dhruvkumar M PatelDepartment of Internal Medicine, Louisiana State University, Shreveport, LA, USA.
Maitri M PatelDepartment of Internal Medicine, GCS Medical College, Gujarat Cancer and Research Institute, Ahmedabad, India.
Lalitkumar B PatelDepartment of Pulmonary Medicine, Narendra Modi Medical College, Ahmedabad, India.
Vahin B PatelDepartment of Internal Medicine, B.J. Medical College, Ahmedabad, India.
Mukundkumar V PatelDepartment of Internal Medicine, Annaya College of Medicine and Research, Kalol, Gujarat University, India.
Dhara K PatelDepartment of Pathology, GCS Medical College, Gujarat Cancer and Research Institute, Ahmedabad, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough diuretic-induced Acute Pancreatitis (AP) cases are typically mild to moderate, severe and potentially fatal occurrences can arise. Case Series and Literature Review: We have, herein, presented a series of diuretic-induced AP cases from March 2018 to February 2024 of a 54-year-old woman treated with chlorthalidone, a 45-year-old male treated with hydrochlorothiazide, and a 48-year-old male treated with frusemide. The literature search has identified 26 cases published to date, 10 from frusemide and 16 from thiazide diuretics. The Naranjo adverse reaction probability scale has categorized all three drugs as "probable". All cases have responded to conservative treatment and cessation of the offending drug. Various mechanisms, such as hypersensitization, ischemia, direct cytotoxic effects, hypercalcemia, and dose-dependent idiosyncrasy, have been found to lead to intrapancreatic activation of pancreatic enzymes, resulting in drug-induced AP.

conclusionFurther research into the mechanisms and genetic factors contributing to diureticinduced AP is essential for enabling early diagnosis and management of diuretic-induced AP.

Indexed as

DiureticsFurosemidePancreatitisAcute DiseaseChlorthalidoneFemaleHumansHydrochlorothiazideMaleMiddle AgedChlorthalidoneDiureticsFurosemideHydrochlorothiazideacute pancreatitisadverse reaction of diuretics.chlorthalidoneDiuretic-induced pancreatitisfrusemidehydrochlorothiazide

Identifiers

PMID39360546

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.