Evidence map›Paper›PMID 39359714›Full record

ArticleToxicology research2024

Exploring the potential of selenium nanoparticles and fabricated selenium nanoparticles @vitamin C nanocomposite in mitigating nicotine-induced testicular toxicity in rats.

Rabab F Hindawy, Rana M M Refaat, Atef E Fouda, Mohamed A El-Shishtawy, Adarsh Kumar, Nagi M El-Shafai, Eman M Faruk, Ola E Nafea

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Article in Toxicology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Rabab F HindawyForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Egypt.ORCID https://orcid.org/0000-0002-4234-0834
Rana M M RefaatForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Egypt.
Atef E FoudaForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Egypt.
Mohamed A El-ShishtawyForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Al Nadi Al Ryadi, Qism Benha, Al-Qalyubia Governorate, Benha 13518, Egypt.
Adarsh KumarDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences (AIIMS), AIIMS Campus, Ansari Nagar East, New Delhi, India.ORCID https://orcid.org/0000-0003-1198-3498
Nagi M El-ShafaiNanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, Qism Kafr El-Shaikh, Kafr Al Sheikh First, Kafr El-Sheikh Governorate, Kafrelsheikh 33516, Egypt.ORCID https://orcid.org/0000-0002-7912-9979
Eman M FarukAnatomy Department, College of Medicine, Umm Al-Qura University, College of Medicine, Umm Al-Qura, University, Al Abidiyah, Makkah, Saudi Arabia.ORCID https://orcid.org/0000-0002-8093-2769
Ola E NafeaForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig Rd inside Zagazig University, Shaibet an Nakareyah, Al-Sharqia Governorate, Zagazig 44519, Egypt.ORCID https://orcid.org/0000-0002-6401-5514

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The tobacco epidemic signifies a major public health threat. Nicotine (NIC), a major active constituent in tobacco, impedes male fertility and semen quality. This work is implemented to explore the potential of selenium nanoparticles (SeNPs) and the newly fabricated SeNPs @vitamin C (SeNPs@VITC) nanocomposite in mitigating testicular toxicity induced by NIC. Materials and methods: The six groups of 48 adult Wistar rats were designed as follows: the control group injected intraperitoneally with normal saline, the SeNPs group treated orally with 2 mg/kg of SeNPs, the SeNPs@VITC nanocomposite group treated orally with 2 mg/kg of SeNPs@VITC nanocomposite, the NIC group injected intraperitoneally with 1.25 mL/kg of NIC, the NIC+ SeNPs group received SeNPs plus NIC, and the NIC+ SeNPs@VITC nanocomposite group received SeNPs@VITC nanocomposite plus NIC. Treatments were administered over a 28-day period. Results: NIC treatment significantly caused poor sperm quality, decreased serum testosterone, increased follicle-stimulating hormone (FSH), luteinizing hormone (LH) concentrations, reduced hemoglobin levels, leukocytosis, disrupted testicular oxidant/antioxidant balance, and disorganized testicular structure. The construction of the novel SeNPs@VITC nanocomposite, compared to NIC plus SeNPs alone, demonstrated a more potent ameliorative effect on NIC-induced reproductive toxicity in adult rats. The SeNPs@VITC nanocomposite significantly increased sperm count, reduced the percentage of sperm head abnormalities, lowered both serum FSH and LH concentrations, and improved the hemoglobin response. Conclusions: Both SeNPs and SeNPs@VITC nanocomposite alleviated the testicular toxicity induced by NIC, but the SeNPs@VITC nanocomposite exhibited superior efficacy. The SeNPs@VITC nanocomposite could be employed to advance enhanced therapeutic strategies for addressing male infertility.

Indexed as

nanocompositenicotinereproductive toxicityselenium nanoparticlestesticular toxicityVitamin C

Identifiers

PMID39359714
PMCPMC11442148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.