Evidence map›Paper›PMID 39359452›Full record

ReviewCaspian journal of internal medicine2024

Prognostic importance of NUP98-rearrangements in acute myeloid leukemia: A systematic review and meta-analysis.

Maryam Sheikhi, Payam Siyadat, Mehrdad Rostami, Mohammad Hadi Sadeghian, Elnaz Zahiri, Mohammad Ghorbani, Hossein Ayatollahi, Amirali Ayatollahi, Reza Hemmatan Attarbashi, Zahra Khoshnegah

Abstract readReview
In one paragraph

Review in Caspian journal of internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maryam SheikhiCancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Payam SiyadatBlood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Mehrdad RostamiDepartment of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Hadi SadeghianCancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Elnaz ZahiriDepartment of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad GhorbaniDepartment of Pathology, Gonabad University of Medical Sciences, Gonabad, Iran.
Hossein AyatollahiCancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amirali AyatollahiCancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza Hemmatan AttarbashiCancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra KhoshnegahDepartment of Laboratory Hematology and Blood Banking, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: NUP98 gene fusions in acute myeloid leukemia (AML) have recently attracted much interest. Despite substantial research illuminating the roles of NUP98 fusions in the course of AML, their impacts on the outcome of patients with AML should be explored in more detail. As a result, this meta-analysis was designed to provide further light on the prognostic implications of NUP98 fusions in AML. Methods: We completed an extensive search in PubMed, Scopus, and Web of Science to identify papers evaluating the prognostic effects of NUP98 rearrangements in patients with AML until August 22, 2022. In total, 15 publications with 6142 participants fulfilled the requirements for the current meta-analysis. All the qualified studies were examined for information regarding HRs and 95% confidence interval (95%CI) for overall survival (OS) and event-free survival (EFS). In addition, we utilized Comprehensive Meta-analysis software version 2 (CMA2) for calculating pooled HRs and 95% CI. Section Title: Our Conclusions: NUP98 fusions could significantly impact the outcome of patients with AML. The use of these fusions as prognostic indicators in AML seems rational.

Indexed as

Acute myeloid leukemiaNucleoporin98NUP 98Prognosis

Identifiers

PMID39359452
PMCPMC11444110

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.