Evidence map›Paper›PMID 39359417›Full record

ArticleFrontiers in endocrinology2024

The efficacy of orally administered L-carnitine in alleviating ovarian dysfunctions has laid the foundation for targeted

Wenjie Zhao, Kunkun Liu, Yuhua Zhang, Pingping Sun, Ernest Zeringue, Li Meng, Huagang Ma

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07783399 (The Effects of Carnitine Supplementation on Oocyte Yield and Quality in Women Undergoing IVF), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07783399 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Carnitine Supplementation on Oocyte Yield and Quality in Women Undergoing IVF

TypeinterventionalSponsorThe Obstetrics and Gynaecology Clinic Narodni FrontRan2026 to 2026Enrolled70ConditionsInfertility (IVF Patients)ArmsL-Carnitine Group
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenjie ZhaoReproductive Medicine Center, Weifang People's Hospital, Weifang, Shandong, China.
Kunkun LiuReproductive Medicine Center, Weifang People's Hospital, Weifang, Shandong, China.
Yuhua ZhangReproductive Medicine Center, Weifang People's Hospital, Weifang, Shandong, China.
Pingping SunReproductive Medicine Center, Weifang People's Hospital, Weifang, Shandong, China.
Ernest ZeringueIVF Laboratories, California IVF Fertility Center, Sacramento, CA, United States.
Li MengIVF Laboratories, California IVF Fertility Center, Sacramento, CA, United States.
Huagang MaReproductive Medicine Center, Weifang People's Hospital, Weifang, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate the effectiveness of oral L-carnitine administration in patients after treatment failure to lay the groundwork for targeted Methods and materials: A total of 515 Results: Following PSM, initial differences in BMI and Day3 top-quality embryo rate between groups were nullified, we created two comparable cohorts with highly similar characteristics. In the subsequent cycles, the study group showed significant improvements in Conclusion: We theorized that daily oral intake of L-carnitine before oocyte retrieval could boost oocyte quality and embryonic development, thus improving IVF outcomes. Ongoing investigations hold the potential to offer valuable insights into the applications and mechanisms underlying the therapeutic effectiveness of L-carnitine.

Indexed as

CarnitineFertilization in VitroPropensity ScoreAdministration, OralAdultFemaleHumansInfertility, FemaleOocyte RetrievalOvarian DiseasesPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeCarnitineblastocyst formationL-carnitinenormal fertilizationoocytepropensity score matching

Identifiers

PMID39359417
PMCPMC11445680

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.