Evidence map›Paper›PMID 39359161›Full record

ArticleBritish journal of haematology2024

Piecing together the intricate puzzle of organ recovery in AL amyloidosis.

Mario Nuvolone, Giovanni Palladini

Abstract read
In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mario NuvoloneDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.ORCID https://orcid.org/0000-0001-8334-1684
Giovanni PalladiniDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.

Funding

CARIPLO Foundation GJC23044European Joint Program on Rare Diseases EJPRD22-169European Union PNRR-MR1-2022-12376853Italian Ministry of Health GR-2018-12 368 387Italian Ministry of Research and Education PRIN 20207XLJB2Telethon Foundation GJC23044
6 · The paper itself

Abstract

In AL amyloidosis, the factors hindering organ recovery despite deep haematological responses to anti-clonal therapy remain elusive. The study by Staron and colleagues identifies tissue-specific factors influencing the lack of organ response, including host-related characteristics, the properties of the amyloidogenic precursor, the extent of organ compromise at diagnosis and the dynamics and depth of haematological response. While this study begins to unravel the complex mechanisms underlying organ recovery in AL amyloidosis, it also raises critical questions that warrant further investigation through future collaborative research. Commentary on: Staron et al. Factors impeding organ recovery despite a deep haematological response in patients with systemic AL amyloidosis. Br J Haematol 2024; 205:2268-2272.

Indexed as

Immunoglobulin Light-chain AmyloidosisHumanslight chain (AL) amyloidosismonoclonal gammopathiesorgan response

Identifiers

PMID39359161
PMCPMC11637724

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.