Evidence map›Paper›PMID 39359021›Full record

ArticleNeuropathology : official journal of the Japanese Society of Neuropathology2025

Nasal immature teratoma in an elderly patient: Clinicopathological and epigenetic analogies with central nervous system counterparts, alongside genomic divergences.

Shintaro Inoue, Hirokazu Takami, Shota Tanaka, Masashi Nomura, Shunsaku Takayanagi, Yuki Saito, Shu Kikuta, Kenji Kondo, Reiko Matsuura, Masako Ikemura and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropathology : official journal of the Japanese Society of Neuropathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shintaro InoueDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.ORCID https://orcid.org/0009-0008-7172-9903
Hirokazu TakamiDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.
Shota TanakaDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.
Masashi NomuraDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.
Shunsaku TakayanagiDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.
Yuki SaitoDepartment Otolaryngology, Head and Neck Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Shu KikutaDepartment Otolaryngology, Head and Neck Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Kenji KondoDepartment Otolaryngology, Head and Neck Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Reiko MatsuuraDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.
Masako IkemuraDepartment Pathology, The University of Tokyo Hospital, Tokyo, Japan.
Sho YamazawaDepartment Pathology, The University of Tokyo Hospital, Tokyo, Japan.
Masao MatsutaniDepartment of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan.
Ryo NishikawaDepartment of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan.
Yuko MatsushitaDepartment of Brain Disease Translational Research, Juntendo University Faculty of Medicine, Tokyo, Japan.
Koichi IchimuraDepartment of Brain Disease Translational Research, Juntendo University Faculty of Medicine, Tokyo, Japan.
Nobuhito SaitoDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.

Funding

Japan Society for the Promotion of Science
6 · The paper itself

Abstract

Germ cell tumors (GCTs) are categorized as gonadal or extra-gonadal, based on the origin. Extra-gonadal GCTs predominantly manifest within the central nervous system (CNS), mediastinum, retroperitoneum, and sacrococcygeal region. These malignancies are most frequently diagnosed in the pediatric, adolescent, and young adult demographics. Incidences of GCT within the nasal cavity are notably scarce, with only six cases documented. This report details the case of a 70-year-old man who presented with a left nasal mass ultimately diagnosed as immature teratoma. A remarkable aspect of this case was the detection of SMARCA4 (BRG1) loss through immunohistochemical analysis. In addition, methylation profiling aligned this case with CNS GCTs, specifically those classified as non-germinomatous GCTs. This molecular characterization informed a tailored therapeutic strategy incorporating carboplatin and etoposide, alongside localized irradiation. This individualized treatment regimen achieved favorable outcomes, with the patient remaining recurrence free for over three years. This highlights the need for precise therapeutic approaches in the management of extragonadal GCTs, particularly those arising in atypical anatomical locations. The present case accentuates the significance of thorough diagnostic evaluations and customized treatment plans for rare GCT presentations. Further empirical and clinical investigations are warranted to enhance our understanding of and refine therapeutic protocols for such exceptional cases.

Indexed as

Nose NeoplasmsTeratomaAgedCentral Nervous System NeoplasmsDNA HelicasesEpigenesis, GeneticHumansMaleNuclear ProteinsTranscription FactorsDNA HelicasesNuclear ProteinsSMARCA4 protein, humanTranscription Factorsbrain tumorgerm cell tumorimmature teratomaintranasal tumor teratoma

Identifiers

PMID39359021
PMCPMC11962582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.