Evidence map›Paper›PMID 39358935›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2024

Engineered Shape-Morphing Transitions in Hydrogels Through Suspension Bath Printing of Temperature-Responsive Granular Hydrogel Inks.

Keisuke Nakamura, Nikolas Di Caprio, Jason A Burdick

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Article
  4. 3D printable tough hydrogel actuators.Materials horizons · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Biomaterials in organoid research: current state and future directions.Frontiers in bioengineering and biotechnology · 2026
    Review
  10. Article
  11. Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels.bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Keisuke NakamuraBioFrontiers Institute, University of Colorado Boulder, Boulder, CO, 80303, USA.
Nikolas Di CaprioBioFrontiers Institute, University of Colorado Boulder, Boulder, CO, 80303, USA.
Jason A BurdickBioFrontiers Institute, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID https://orcid.org/0000-0002-2006-332X

Funding

Engineered Granular Hydrogels for Endogenous Tissue RepairR01HL160616 · NHLBI · UNIVERSITY OF COLORADO · PI BURDICK, JASON A · 2022 to 2025
$2.5M
Engineered Developmental Microenvironments: Cartilage Formation and MaturationR01AR077362 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BURDICK, JASON A, MAUCK, ROBERT L · 2020 to 2024
$2.5M
Biofabrication Training ProgramT32EB034215 · NIBIB · UNIVERSITY OF COLORADO · PI Stephanie J Bryant, Jason A Burdick · 2024 to 2026
$512k
Japan Society for the Promotion of ScienceNHLBI NIH HHS R01 HL160616NIAMS NIH HHS R01 AR077362NIBIB NIH HHS T32 EB034215NIH HHS R01 AR077362NIH HHS R01 HL160616
6 · The paper itself

Abstract

4D printing of hydrogels is an emerging technology used to fabricate shape-morphing soft materials that are responsive to external stimuli for use in soft robotics and biomedical applications. Soft materials are technically challenging to process with current 4D printing methods, which limits the design and actuation potential of printed structures. Here, a simple multi-material 4D printing technique is developed that combines dynamic temperature-responsive granular hydrogel inks based on hyaluronic acid, whose actuation is modulated via poly(N-isopropylacrylamide) crosslinker design, with granular suspension bath printing that provides structural support during and after the printing process. Granular hydrogels are easily extruded upon jamming due to their shear-thinning properties and their porous structure enables rapid actuation kinetics (i.e., seconds). Granular suspension baths support responsive ink deposition into complex patterns due to shear-yielding to fabricate multi-material objects that can be post-crosslinked to obtain anisotropic shape transformations. Dynamic actuation is explored by varying printing patterns and bath shapes, achieving complex shape transformations such as 'S'-shaped and hemisphere structures. Furthermore, stepwise actuation is programmed into multi-material structures by using microgels with varied transition temperatures. Overall, this approach offers a simple method to fabricate programmable soft actuators with rapid kinetics and precise control over shape morphing.

Indexed as

4D printinggranular hydrogelsmulti‐material printingshape‐morphing hydrogelssuspension bath printing

Identifiers

PMID39358935
PMCPMC11588557

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.