Evidence map›Paper›PMID 39358737›Full record

ArticleGenome biology2024

A genome-wide association study reveals molecular mechanism underlying powdery mildew resistance in cucumber.

Xuewen Xu, Yujiao Du, Suhao Li, Ming Tan, Hamza Sohail, Xueli Liu, Xiaohua Qi, Xiaodong Yang, Xuehao Chen

Abstract read
In one paragraph

Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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  6. L-Lysine fromInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuewen XuSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Yujiao DuSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Suhao LiSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Ming TanSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Hamza SohailSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Xueli LiuSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Xiaohua QiSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Xiaodong YangSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China. yxd@yzu.edu.cn.
Xuehao ChenSchool of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, Jiangsu, 225009, China. xhchen@yzu.edu.cn.ORCID http://orcid.org/0000-0002-5834-8750

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPowdery mildew is a disease with one of the most substantial impacts on cucumber production globally. The most efficient approach for controlling powdery mildew is the development of genetic resistance; however, few genes associated with inherent variations in cucumber powdery mildew resistance have been identified as of yet.

resultsIn this study, we re-sequence 299 cucumber accessions, which are divided into four geographical groups. A genome-wide association study identifies 50 sites significantly associated with natural variations in powdery mildew resistance. Linkage disequilibrium analysis further divides these 50 sites into 32 linkage disequilibrium blocks containing 41 putative genes. Virus-induced gene silencing and gene expression analysis implicate CsGy5G015960, which encodes a phosphate transporter, as the candidate gene regulating powdery mildew resistance. On the basis of the resequencing data, we generate five CsGy5G015960 haplotypes, identifying Hap.1 as the haplotype most likely associated with powdery mildew resistance. In addition, we determine that a 29-bp InDel in the 3' untranslated region of CsGy5G015960 is responsible for mRNA stability. Overexpression of CsGy5G015960

conclusionsHere we identify a candidate powdery mildew-resistant gene in cucumber using GWAS. The identified gene may be a promising target for molecular breeding and genetic engineering in cucumber to enhance powdery mildew resistance.

Indexed as

Cucumis sativusDisease ResistanceGenome-Wide Association StudyLinkage DisequilibriumPlant DiseasesAscomycotaGene Expression Regulation, PlantHaplotypesPlant ProteinsPlant ProteinsCucumberGWASH2O2Phosphate transporterPowdery mildew

Identifiers

PMID39358737
PMCPMC11445940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.