ArticleGenome biology2024
A genome-wide association study reveals molecular mechanism underlying powdery mildew resistance in cucumber.
Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Pangenome-resolved structural variation drives adaptation and trait evolution in cucumber.Nature genetics · 2026Article
- Genomics assisted breeding for mildew resistance in cucumber: from gene discovery to future innovations.Plant molecular biology · 2026Review
- Review
- Integrated genome-wide domestication and association analyses reveal the complex genetic basis of parthenocarpy during cucumber domestication.Molecular horticulture · 2026Article
- Harnessing Nanoparticles and Nanosuspensions to Combat Powdery Mildew: A Frontier in Vegetable and Fruit Protection.Journal of fungi (Basel, Switzerland) · 2025Review
- L-Lysine fromInternational journal of molecular sciences · 2025Article
- Unraveling the Intricacies of Powdery Mildew: Insights into Colonization, Plant Defense Mechanisms, and Future Strategies.International journal of molecular sciences · 2025Review
- Article
- Celery flavonoid-rich extract significantly reduces cucumber powdery mildew severity and enhances plant defense responses.Scientific reports · 2025Article
- A genome-wide association study reveals molecular mechanism underlying powdery mildew resistance in cucumber.Genome biology · 2024Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPowdery mildew is a disease with one of the most substantial impacts on cucumber production globally. The most efficient approach for controlling powdery mildew is the development of genetic resistance; however, few genes associated with inherent variations in cucumber powdery mildew resistance have been identified as of yet.
resultsIn this study, we re-sequence 299 cucumber accessions, which are divided into four geographical groups. A genome-wide association study identifies 50 sites significantly associated with natural variations in powdery mildew resistance. Linkage disequilibrium analysis further divides these 50 sites into 32 linkage disequilibrium blocks containing 41 putative genes. Virus-induced gene silencing and gene expression analysis implicate CsGy5G015960, which encodes a phosphate transporter, as the candidate gene regulating powdery mildew resistance. On the basis of the resequencing data, we generate five CsGy5G015960 haplotypes, identifying Hap.1 as the haplotype most likely associated with powdery mildew resistance. In addition, we determine that a 29-bp InDel in the 3' untranslated region of CsGy5G015960 is responsible for mRNA stability. Overexpression of CsGy5G015960
conclusionsHere we identify a candidate powdery mildew-resistant gene in cucumber using GWAS. The identified gene may be a promising target for molecular breeding and genetic engineering in cucumber to enhance powdery mildew resistance.
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