Evidence map›Paper›PMID 39358733›Full record

ArticleBMC cancer2024

Comparison of long-term quality of life and their predictors in survivors between paediatric and adult nasopharyngeal carcinoma in the intensity-modulated radiotherapy era.

Jing Jin, Shan-Shan Guo, Li-Ting Liu, Dong-Xiang Wen, Rong-Ping Liu, Jie-Yi Lin, Si-Qi Liu, Xue-Song Sun, Yu-Jing Liang, Lin-Quan Tang and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Pediatric Nasopharyngeal Carcinoma (NPC).Current oncology reports · 2026
    Review
  3. Applications of machine learning and natural language processing to neurocognitive outcomes in posttreatment cancer survivors: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jing Jin *Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China.
Shan-Shan Guo *Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China.
Li-Ting Liu *Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China.
Dong-Xiang Wen *Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China.
Rong-Ping LiuDepartment of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China.
Jie-Yi LinDepartment of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China.
Si-Qi LiuDepartment of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China.
Xue-Song SunDepartment of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China.
Yu-Jing LiangDepartment of Radiology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, Guangzhou, 510060, P. R. China.
Lin-Quan Tang *Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China. tanglq@sysucc.org.cn.
Hai-Qiang Mai *Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China. maihq@sysucc.org.cn.
Qiu-Yan Chen *Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-sen University Cancer Centre, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China. chenqy@sysucc.org.cn.

Funding

Guangdong Major Project of Basic and Applied Basic Research HRB103Innovative Research Team of High-level Local University in Shanghai SSMU-ZLCX20180500National Key Research and Development Program of China 2022YFC2705005, 2022YFC2505800National Natural Science Foundation of China 32200651, 82203776, 82203125, 82222050, 82272739, 82272882, 82173287, 82073003, 82003267, 82002852Natural Science Foundation of Guangdong Province for Distinguished Young Scholar 2018B030306001Pearl River S&T Nova Program of Guangzhou 201806010135Planned Science and Technology Project of Guangdong Province 2019B020230002Sun Yat-sen University Clinical Research 5010 Program No. 201315, 2015021, 2017010, 2019023
6 · The paper itself

Abstract

backgroundTo compare the differences in long-term quality of life (QoL) between survivors of paediatric and adult patients with nasopharyngeal carcinoma (NPC) and assess the clinical factors that predict long-term QoL.

methodsWe enrolled 420 long-term NPC survivors who were alive for at least 8 years after treatment, including 195 paediatric and 225 adult patients diagnosed and treated with intensity-modulated radiotherapy (IMRT) at Sun Yat-sen University Cancer Centre (SYSUCC) between 2011 and 2015. Data on clinical factors and EORTC QLQ-C30 were collected from all participants. The QoL of paediatric and adult NPC survivors was compared.

resultsThe paediatric group had significantly better outcomes in global health status (paediatric: 80.2 ± 12.7; adult: 77.2 ± 11.5; P = 0.027), physical function (paediatric: 98.5 ± 4.6; adult: 95.1 ± 7.0; P < 0.001), role function (paediatric: 97.0 ± 9.2; adult: 90.5 ± 15.2; P < 0.001), social function (paediatric: 96.0 ± 8.9; adult: 93.5 ± 11.8; P = 0.038), insomnia (paediatric: 1.9 ± 7.8; adult: 13.1 ± 22.3; P < 0.001), constipation (paediatric: 1.3 ± 7.5; adult: 8.0 ± 17.4; P < 0.001), diarrhea (paediatric: 0.7 ± 4.6; adult: 2.8 ± 9.3; P = 0.010), and financial difficulties (paediatric: 1.9 ± 7.8; adult: 11.0 ± 19.8; P < 0.001), but poorer cognitive function (paediatric: 88.3 ± 9.9; adult: 93.8 ± 12.6; P < 0.001) than the adult group. Pretreatment clinical factors, including T stage, N stage, and pre-treatment EBV (Epstein-Barr Virus) DNA, showed a strong association with QoL. However, the factors that affected the QoL outcomes differed between the two groups. In survivors of paediatric cancer, global health status/QoL was strongly correlated with T stage (P < 0.001) and clinical stage (P = 0.018), whereas it was strongly correlated with pre-treatment EBV DNA (P = 0.008) in adults.

conclusionPaediatric survivors of NPC have a significantly better QoL than adult NPC survivors. Moreover, pre-treatment T stage, N stage, and EBV DNA significantly influenced the overall health status of the survivors. These results highlight the need to tailor care to both age groups to promote better long-term health outcomes.

Indexed as

Cancer SurvivorsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsQuality of LifeRadiotherapy, Intensity-ModulatedAdolescentAdultAgedChildFemaleHealth StatusHumansMaleMiddle AgedYoung AdultAdult NPCCancer survivorsLong-term quality of lifeNasopharyngeal carcinoma (NPC)Paediatric NPC

Identifiers

PMID39358733
PMCPMC11447939

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