Evidence map›Paper›PMID 39358725›Full record

Observational studyBMC public health2024

HIV incidence and its associated factors among young adults with multiple sexual partners in Maputo, Mozambique: a vaccine preparedness study.

Ivalda Macicame, Nilesh Bhatt, Edna Viegas, Adam Yates, Chiaka Nwoga, Raquel Matavele Chissumba, Vanessa Monteiro, Michelle Imbach, Mark Milazzo, Qun Li and 10 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ivalda MacicameInstituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.
Nilesh BhattInstituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.
Edna ViegasInstituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.
Adam YatesU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Chiaka NwogaU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Raquel Matavele ChissumbaInstituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.
Vanessa MonteiroInstituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.
Michelle ImbachU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Mark MilazzoU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Qun LiU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Steven SchechU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Tsedal MebrahtuU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Leigh Anne EllerU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Edith SwannDivision of AIDS, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Nelson L MichaelU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Merlin L RobbU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Trevor A CrowellU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA. tcrowell@hivresearch.org.
Christina S PolyakU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, 6720A Rockledge Drive, Suite 400 Silver Spring, Bethesda, MD, 20817, USA.
Ilesh JaniInstituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.
RV363 Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSub-Saharan Africa has a high burden of HIV, particularly among female sex workers (FSW) and men who have sex with men (MSM). Future clinical trials to evaluate vaccines and other interventions to prevent HIV will need to enroll populations with high HIV incidence. We conducted an observational study of HIV incidence among men and women with multiple sexual partners-including MSM and FSW-in Maputo, Mozambique, in order to prepare the country to conduct future efficacy trials of candidate HIV vaccines and other HIV prevention products.

methodsWe conducted a prospective observational HIV incidence study in Maputo, Mozambique, that enrolled adults aged 18-35 years, without HIV, who had two or more sexual partners in the preceding three months. Recruitment strategies prioritized participation of MSM and FSW. Participants were followed for 24 months with HIV-1 testing every 3 months and staff-administered behavioral questionnaires every 6 months. Cox proportional hazard modeling was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for factors potentially associated with HIV acquisition.

resultsFrom January 2014 to October 2017, 505 adults without HIV were enrolled with median age of 21 years (interquartile range:19-24); 41% were female and 82% were single. There were 19 HIV seroconversions (10 female and 9 male) during 943 person-years (PY) of observation (overall HIV incidence 2.02/100PY; 95%CI 1.21-3.15). The highest HIV incidence was observed among sex workers (2.08/100PY; 95%CI 0.25-7.52) and MSM (19.18/100PY; 95%CI 3.96-56.06). Increased hazard of incident HIV was observed among participants who were MSM (HR = 27.95, 95%CI 4.39-117.94), p = 0.0004), reported three or more sexual partners at enrollment (HR = 7.39, 95%CI 1.64-33.25, p = 0.009), and indicated ever having a sexual partner living with HIV (HR = 9.64, 95%CI 2.23-41.71, p = 0.002).

conclusionOur findings may inform inclusion criteria for upcoming clinical trials of HIV prevention interventions, including vaccine candidates, which may prioritize enrollment of MSM, people with more than three sexual partners, and people with sexual partners who are living with HIV. These same populations are in need of further intervention to reduce HIV incidence.

Indexed as

HIV InfectionsSexual PartnersSex WorkersAdolescentAdultAIDS VaccinesFemaleHomosexuality, MaleHumansIncidenceMaleMozambiqueProspective StudiesRisk FactorsSexual BehaviorYoung AdultAIDS VaccinesAcquired immunodeficiency syndromeAfrica South of the SaharaRisk factorsSexual and gender minoritiesSexual behavior key populations

Identifiers

PMID39358725
PMCPMC11446008

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.