ArticleInternational journal of dermatology2025
Novel imaging techniques for tumor margin detection in basal cell carcinoma: a systematic scoping review of FDA and EMA-approved imaging modalities.
Article in International journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of Facial Artery Course Variations, Diameters, and Depth Using Doppler Ultrasonography: A Systematic Review and Meta-Analysis.Journal of cosmetic dermatology · 2025Pooled it
- Ex Vivo High-Frequency Ultrasound of the Skin in the Morphologic Assessment of Basal Cell Carcinoma: A Comparative Study.Diagnostics (Basel, Switzerland) · 2026Article
- Photoacoustic imaging-based assessment of vascular changes in scars: a retrospective analysis of factors influencing PDL treatment efficacy.Lasers in medical science · 2026Article
- Exploratory systematic characterization of vascular features in confocal laser endomicroscopy of cutaneous squamous cell carcinoma.Oral and maxillofacial surgery · 2026Article
- Clinical Patterns in Patients with Basal Cell Carcinoma: A 10-Year Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Reflectance confocal microscopy detects distinct features of field damage in chronically UV-irradiated SKH1 mouse skin.JID innovations : skin science from molecules to population health · 2026Article
- Line-field confocal optical coherence tomography for diagnosis and treatment monitoring of subtle basal cell carcinomas in a patient with nevoid basal cell carcinoma syndrome.JAAD case reports · 2026Article
- Cost and cost-effectiveness of Mohs micrographic surgery versus conventional excision for nonmelanoma skin cancer: A scoping review.JAAD international · 2026Review
- Surgical Management of Cutaneous Neoplasms: Biopsy Strategies, Margin Assessment, and Special Considerations.Dermatopathology (Basel, Switzerland) · 2026Review
- Multimodal Non-Invasive Skin Imaging in Dermatology: Current Modalities, Clinical Applications, and Future Integration.Diagnostics (Basel, Switzerland) · 2026Review
- Retrospective Analysis of the Therapeutic Outcomes of Microneedle Radiofrequency on Melasma by Optical Coherence Tomography: A Observational Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Surgical Outcomes of Nonmelanoma Skin Cancer Managed with Systematic Preoperative Reflectance Confocal Microscopy-Guided Margin Assessment: A Retrospective Cohort Study Comparing Wide Local Excision and Mohs Micrographic Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Current and Future Perspectives in Mohs Micrographic Surgery for Non-Melanoma Skin Cancers: A Narrative Review.Journal of clinical medicine · 2026Review
- Characterization of dermatofibromas and epidermoid cysts using dermoscopy-guided high-frequency ultrasound imaging.Journal of ultrasound · 2026Article
- Dermoscopic and Reflectance Confocal Microscopic Features of a Primary Cutaneous Anaplastic Large Cell Lymphoma (C-ALCL) of the Eyelid: A Case Report with Histopathologic Correlation.Reports (MDPI) · 2026Article
- Intraoperative Margin Control in Eyelid Tumor Surgery: Current Standards, Imaging Advances, and Emerging Techniques.Current oncology (Toronto, Ont.) · 2026Review
- ChatGPT, Gemini, and Claude in clinical and dermoscopic image analysis of basal cell carcinoma and its common mimickers: A comparative performance analysis.JID innovations : skin science from molecules to population health · 2026Article
- Dermoscopy-guided high-frequency ultrasound: Principles and applications in dermatology.JID innovations : skin science from molecules to population health · 2026Article
- Efficacy of 4% 5-Fluorouracil Cream in the Treatment of Actinic Keratoses: A Single-Center Experience.Journal of clinical medicine · 2026Article
- Dermoscopy-Guided High-Frequency Ultrasound Imaging of Subcentimeter Cutaneous and Subcutaneous Neurofibromas in Patients with Neurofibromatosis Type 1.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Mohs micrographic surgery (MMS) is the gold standard for removing basal cell carcinomas (BCCs) due to its ability to guarantee 100% margin evaluation through frozen section histopathology, offering the highest cure rate among current treatments. However, noninvasive imaging technologies have emerged as promising alternatives to clinical assessment for defining presurgical margins. This systematic scoping review examines the efficacy of these imaging modalities, focusing on those approved for clinical use by the United States Food and Drug Administration (FDA) or the European Medicines Agency (EMA). A systematic search of EMBASE, Scopus, PubMed, and the Cochrane Public Library databases identified 11 relevant studies out of 2123 records, encompassing 644 lesions across five imaging techniques. The findings suggest that dermoscopy, high-frequency ultrasound (HFUS), optical coherence tomography (OCT), line-field optical coherence tomography (LC-OCT), and reflectance confocal microscopy (RCM) show potential in detecting BCC margins, which could enhance MMS by providing better preoperative planning, informing patients of expected defect size, aiding in reconstruction decisions, and reducing overall procedure costs. This review discusses the benefits and limitations of each technique, offering insights into how these innovations could influence the future of BCC management. Emerging imaging techniques could enhance MMS by improving BCC margin assessment and reducing costs. Their adoption will depend on price and ease of use.
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Registered trials
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