ArticleClinical oral investigations2024
Is there an association between salivary immune and microbial profile with dental health in systematically healthy children?
Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Oral and dental status in children with intestinal failure: A descriptive cross-sectional study.JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Association of salivary proteins with periodontal disease in children and adolescents- a scoping review.BMC oral health · 2026Article
- Salivary trimethylamine N-oxide: a novel non-invasive marker for periodontal inflammation.Clinical oral investigations · 2025Article
- Therapeutic effect of permeable resin and composite resin filling combined with self-etching adhesive in the treatment of dental caries in children.American journal of translational research · 2025Article
- Association between Salivary Cortisol, Secretory IgA, and Inflammatory Cytokines with Early Childhood Caries: A Cross-sectional Analytical Study.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to characterize the inflammatory profile of systemically healthy children's saliva and its association with clinical diagnoses of caries and gingival inflammation. MATERIALS AND
methodsUnstimulated saliva was collected from 100 children before clinical dental examinations. The saliva samples were analyzed for total protein and specific inflammatory cytokines (IL-10, IL-8, IL-6, and TNFα) with Bradford and ELISA assays, respectively. Salivary bacteria were quantified using a quantitative real-time polymerase chain assay. The salivary values were then correlated with age, DMFT index, plaque index (PI), and gingival index (GI).
resultsThe mean age of the cohort was 8.08 ± 0.23 years with 49% females, the mean DMF of the cohort was 2.64 ± 0.31, the mean GI was 0.51 ± 0.06, and the mean PI was 1.33 ± 0.07. Significant correlations were found between PI with DMFT and GI. Children with DMFT > 2 had significantly higher levels of IL-8 compared with children with DMFT ≤ 2. IL-6 and TNFα were significantly higher among children with PI > 1 than among children with PI ≤ 1.
conclusionsSalivary cytokine were found to be associate with clinical parameters as DMFT and PI, thus may be a potential tool that reflects dental health status. CLINICAL RELEVANCE: The presence of salivary cytokines in children may reflect evaluation of dental caries and oral inflammation.
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