Evidence map›Paper›PMID 39358526›Full record

ArticleNature2024

The fly connectome reveals a path to the effectome.

Dean A Pospisil, Max J Aragon, Sven Dorkenwald, Arie Matsliah, Amy R Sterling, Philipp Schlegel, Szi-Chieh Yu, Claire E McKellar, Marta Costa, Katharina Eichler and 3 more

Abstract readValidation Study
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A neural manifold view of the brain.Nature neuroscience · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Local Differences in Network Organization in the Auditory and Parietal Cortex, Revealed with Single Neuron Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Review
  18. Fly connectome over the wire.Nature reviews. Neuroscience · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dean A Pospisil *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. dp4846@princeton.edu.ORCID 0000-0002-5793-2517
Max J Aragon *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. mjaragon@princeton.edu.ORCID 0000-0001-6935-0381
Sven DorkenwaldPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Arie MatsliahPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Amy R SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Philipp SchlegelNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-5633-1314
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0001-9684-0156
Claire E McKellarPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Marta CostaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5948-3092
Katharina EichlerDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Gregory S X E JefferisNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-0587-9355
Mala MurthyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-3063-3389
Jonathan W PillowPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.

Funding

Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Uncovering the Neural Mechanisms that Flexibly Link Sensory Processing to BehaviorR35NS111580 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2019 to 2026
$5.0M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
Dissecting Sensorimotor Pathways Underlying Social Interactions: Models, Circuits, and BehaviorR01NS104899 · NINDS · PRINCETON UNIVERSITY · PI BIALEK, WILLIAM, MURTHY, MALA · 2018 to 2022
$2.4M
Accelerating connectomic proofreading for larger brains and multiple individualsRF1MH129268 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA · 2022 to 2022
$2.1M
Adaptive statistical algorithms for learning and control of neural dynamicsRF1DA056404 · NIDA · PRINCETON UNIVERSITY · PI PARK, IL MEMMING, PILLOW, JONATHAN WILLIAM · 2022 to 2022
$969k
NIDA NIH HHS RF1 DA056404NIMH NIH HHS RF1 MH117815NIMH NIH HHS RF1 MH129268NINDS NIH HHS R01 NS104899NINDS NIH HHS R35 NS111580NINDS NIH HHS U24 NS126935Wellcome Trust 203261/Z/16/Z
6 · The paper itself

Abstract

A goal of neuroscience is to obtain a causal model of the nervous system. The recently reported whole-brain fly connectome

Indexed as

BrainConnectomeDrosophila melanogasterNeural PathwaysNeuronsAnimalsFemaleLinear ModelsModels, NeurologicalOptogeneticsReproducibility of ResultsStochastic Processes

Identifiers

PMID39358526
PMCPMC11446844

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.