Evidence map›Paper›PMID 39358424›Full record

ArticleScientific reports2024

Optimization and pharmacological evaluation of phytochemical-rich Cuscuta reflexa seed extract for its efficacy against chlorpyrifos-induced hepatotoxicity in murine models.

Tahira Batool, Sobia Noreen, Fozia Batool, Gamal A Shazly, Shahid Iqbal, Ali Irfan, Saira Batool, Shazia Akram Ghumman, Maryam Basharat, Sara Hasan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Efficacy of Ma'aljobon Aftimouni (Contemporary clinical trials communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tahira BatoolInstitute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.
Sobia NoreenInstitute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan. sobia.noreen@uos.edu.pk.
Fozia BatoolInstitute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.
Gamal A ShazlyDepartment of Pharmaceutics, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Shahid IqbalDepartment of Chemistry, University of Education Lahore-Faisalabad Campus, Faisalabad, 37630, Pakistan.
Ali IrfanDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Saira BatoolDepartment of Zoology, University of Sargodha, Sargodha, 40100, Pakistan.
Shazia Akram GhummanCollege of Pharmacy, University of Sargodha, Sargodha, 40100, Pakistan.
Maryam BasharatInstitute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.
Sara HasanSchool of Chemistry and Physics, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD, 4000, Australia.
Samina AslamDepartment of Chemistry, The Women University Multan, Multan, 6000, Pakistan.
Yousef A Bin JardanDepartment of Pharmaceutics, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia. ybinjardan@ksu.edu.sa.

Funding

King Saud University RSP2024R457
6 · The paper itself

Abstract

The popular organophosphorus (OP) compound chlorpyrifos (CP) has recently gained significant attention due to its health risks, particularly among farmers exposed to OP pesticides. This study aimed to evaluate the acute toxicity of Cuscuta reflexa seed extract (CRSE) and its efficacy of mitigating the adverse effects of CP in albino male mice. For acute toxicity analysis, the first group was served as the control group, while the second group was received CRSE (200 mg/kg/bw) on the first day of the 14-day experiment. For hepatotoxicity analysis, the first group was the control group, the second group (vehicle control) received corn oil (CO) (2 mL/kg/bw), the third group was given CP (20 mg/kg/bw) dissolved in corn oil and the fourth group was given CP (20 mg/kg/bw) along-with CRSE (200 mg/kg/bw) orally via gavage once daily for 21 days. The acute toxicity examination revealed no statistically significant differences between the CRSE-treated and control groups in serum biochemical indicators and histopathological analyses of various organs, suggesting that CRSE as safe at a dosage of 200 mg/kg/bw, with an oral LD

Indexed as

Chemical and Drug Induced Liver InjuryChlorpyrifosCuscutaLiverPlant ExtractsSeedsAnimalsAntioxidantsDisease Models, AnimalMaleMiceOxidative StressPhytochemicalsAntioxidantsChlorpyrifosPhytochemicalsPlant ExtractsAntioxidantsCuscuta reflexa seed extractHepatotoxicityOxidative stressPesticidesSerum biochemical markers

Identifiers

PMID39358424
PMCPMC11446953

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.