Evidence map›Paper›PMID 39358409›Full record

ArticlePediatric research2025

Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70

Hilde D de Vries, Tim R Eijgenraam, Vincent W Bloks, Niels L Mulder, Tim van Zutphen, Herman H W Silljé, Folkert Kuipers, Jan Freark de Boer

Abstract read
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In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Cardiohepatic Axis in Heart Failure.JACC. Basic to translational science · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hilde D de Vries *Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Tim R Eijgenraam *Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Vincent W BloksDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Niels L MulderDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Tim van ZutphenFaculty Campus Fryslân, University of Groningen, Leeuwarden, The Netherlands.
Herman H W SilljéDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Folkert Kuipers *Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. f.kuipers@umcg.nl.
Jan Freark de Boer *Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. j.f.de.boer@umcg.nl.

Funding

Netherlands Cardiovascular Research (CVON) initiative of the Dutch Heart FoundationNoaber Foundation (Lunteren, the Netherlands)PhD program of Campus Fryslân, University of Groningen and Medical Center Leeuwarden
6 · The paper itself

Abstract

backgroundHigh plasma bile acids (BAs), for instance due to intrahepatic cholestasis of pregnancy or neonatal cholestasis, are associated with cardiac abnormalities. Here, we exploited the variability in plasma BA levels in Cyp2c70

methodsRNA sequencing was performed on hearts of 3-week-old Cyp2c70

resultsWe identified 1355 genes that were differentially expressed in hearts of Cyp2c70

conclusionsElevated plasma BAs alter gene expression profiles of hearts of mice with a human-like BA profile, revealing cardiac stress and inflammation. Our findings support the notion that high plasma BAs induce cardiac complications in early life. IMPACT: Cyp2c70

Indexed as

Bile Acids and SaltsCytochrome P450 Family 2InflammationMyocardiumAnimalsAnimals, NewbornFemaleMiceMice, Inbred C57BLMice, KnockoutTranscriptomeUrsodeoxycholic AcidBile Acids and SaltsCytochrome P450 Family 2Ursodeoxycholic Acid

Identifiers

PMID39358409
PMCPMC12122362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.