Evidence map›Paper›PMID 39358335›Full record

ArticleThe pharmacogenomics journal2024

Clinical and economic outcomes of a pharmacogenomics-enriched comprehensive medication management program in a self-insured employee population.

Maren S Fragala, Murray Keogh, Steven E Goldberg, Raymond A Lorenz, Jeffrey A Shaman

Abstract read
In one paragraph

Article in The pharmacogenomics journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maren S Fragala *Quest Diagnostics, Secaucus, NJ, USA. Maren.S.Fragala@QuestDiagnostics.com.
Murray Keogh *Coriell Life Sciences, Philadelphia, PA, USA.
Steven E GoldbergQuest Diagnostics, Secaucus, NJ, USA.
Raymond A LorenzQuest Diagnostics, Secaucus, NJ, USA.ORCID 0000-0002-6241-1003
Jeffrey A ShamanCoriell Life Sciences, Philadelphia, PA, USA.ORCID 0000-0001-7397-5755

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical and economic outcomes from a pharmacogenomics-enriched comprehensive medication management program were evaluated over 26 months in a self-insured U.S. employee population (n = 452 participants; n = 1500 controls) using propensity matched pre-post design with adjusted negative binomial and linear regression models. After adjusting for baseline covariates, program participation was associated with 39% fewer inpatient (p = 0.05) and 39% fewer emergency department (p = 0.002) visits, and with 21% more outpatient visits (p < 0.001) in the follow-up period compared to the control group. Results show pharmacogenomics-enriched comprehensive medication management can favorably impact healthcare utilization in a self-insured employer population by reducing emergency department and inpatient visits and can offer the potential for cost savings. Self-insured employers may consider implementing pharmacogenomics-enriched comprehensive medication management to improve the healthcare of their employees.

Indexed as

PharmacogeneticsAdultCost SavingsEmergency Service, HospitalFemaleHealth Benefit Plans, EmployeeHumansMaleMedication Therapy ManagementMiddle Aged

Identifiers

PMID39358335
PMCPMC11446811

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.