Evidence map›Paper›PMID 39358301›Full record

ArticleEnvironmental health and preventive medicine2024

Interaction between the oxidative balance score and serum per- and poly-fluoroalkyl substances (PFASs) on liver health: analysis of the NHANES 2007-2018 dataset.

Ren Zhou, Fei Chen, Lei Zhang, Yu Sun, Hong Jiang, Rong Hu, Jia Yan

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Article in Environmental health and preventive medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ren ZhouDepartment of Anesthesiology, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine.
Fei ChenDepartment of Anesthesiology, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine.
Lei ZhangDepartment of Anesthesiology, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine.
Yu SunDepartment of Anesthesiology, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine.
Hong JiangDepartment of Anesthesiology, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine.
Rong HuDepartment of Anesthesiology, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine.
Jia YanDepartment of Anesthesiology, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPer- and poly-fluoroalkyl substances (PFASs) are pervasive synthetic compounds, prompting investigations into their intricate interactions with lifestyle factors and health indicators because of their enduring environmental presence and bioaccumulation. This study aimed to explore the effects of the oxidative balance score (OBS) and PFAS on liver-related indices.

methodsTwenty dietary and lifestyle factors were used to calculate the OBS. The serum concentrations of PFASs were measured, and their sum was calculated for analysis. The levels of liver markers were also evaluated. Linear regression models and interaction analyses were used to assess the associations between OBS, PFAS concentrations, and liver indices.

resultsThe results revealed an inverse association between high OBS and perfluorooctane sulfonic acid concentration, as well as the sum of PFAS concentrations. OBS was positively associated with liver markers. The PFAS concentrations were positively associated with total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels. Interaction analyses revealed significant interactions between OBS and specific PFASs for alkaline phosphatase (interaction P < 0.05). Possible interactions were also found between OBS and specific PFASs for ALT, and AST levels (interaction P < 0.10).

conclusionsThis study clarified the association between total PFAS and OBS. This association was significant mainly for diet-related OBS. PFAS and OBS are associated with liver-related indicators in the blood.

Indexed as

Environmental PollutantsFluorocarbonsLiverNutrition SurveysAdultAgedAlkanesulfonic AcidsBiomarkersEnvironmental ExposureFemaleHumansMaleMiddle AgedOxidative StressYoung AdultAlkanesulfonic AcidsBiomarkersEnvironmental PollutantsFluorocarbonsperfluorooctane sulfonic acidAspartate aminotransferaseBioaccumulationLinear regression modelsLiver markersOxidative balance scorePer- and poly-fluoroalkyl substances

Identifiers

PMID39358301
PMCPMC11446636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.