Evidence map›Paper›PMID 39357987›Full record

ArticleRNA (New York, N.Y.)2024

Identification, characterization, and structure of a tRNA splicing enzyme RNA 5'-OH kinase from the pathogenic fungi Mucorales.

Shreya Ghosh, Gina Wimberly-Gard, Agata Jacewicz, Beate Schwer, Stewart Shuman

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Many paths to destruction: Family-specific turnover and stress responses for tRNA introns.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shreya GhoshMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Gina Wimberly-GardMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Agata JacewiczMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Beate SchwerMicrobiology and Immunology Department, Weill Cornell Medical College, New York, New York 10065, USA.
Stewart ShumanMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA shumans@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
Mechanisms of DNA and RNA TransactionsR35GM126945 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Stewart H Shuman · 2018 to 2026
$8.9M
Inositol pyrophosphate dynamics affect RNA 3'-processing/transcription terminationR01GM134021 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BEATE SCHWER · 2019 to 2026
$2.8M
NCI NIH HHS P30 CA008748NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM134021NIGMS NIH HHS R35 GM126945
6 · The paper itself

Abstract

Fungal Trl1 is an essential tRNA splicing enzyme composed of C-terminal cyclic phosphodiesterase and central polynucleotide kinase end-healing domains that convert the 2',3'-cyclic-PO

Indexed as

Polynucleotide 5'-Hydroxyl-KinaseRNA SplicingRNA, TransferAmino Acid SequenceCrystallography, X-RayFungal ProteinsModels, MolecularMucoralesFungal ProteinsPolynucleotide 5'-Hydroxyl-KinaseRNA, Transferfungal pathogenRNA end healingtRNA splicing

Identifiers

PMID39357987
PMCPMC11571804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.