Evidence map›Paper›PMID 39357850›Full record

ArticleACS infectious diseases2024

High Affinity Inhibitors of the Macrophage Infectivity Potentiator Protein from

Theresa Lohr, Carina Herbst, Nicole M Bzdyl, Christopher Jenkins, Nicolas J Scheuplein, Wisely Oki Sugiarto, Jacob J Whittaker, Albert Guskov, Isobel Norville, Ute A Hellmich and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Theresa LohrInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg, 97074, Germany.
Carina HerbstInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg, 97074, Germany.ORCID 0009-0008-0247-7124
Nicole M BzdylMarshall Centre for Infectious Diseases Research and Training, School of Biomedical Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Australia.
Christopher JenkinsDSTL, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, United Kingdom.
Nicolas J ScheupleinInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg, 97074, Germany.
Wisely Oki SugiartoDepartment of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, Darmstadt 64287, Germany.
Jacob J WhittakerGroningen Institute for Biomolecular Sciences and Biotechnology, University of Groningen, Groningen 9747AG, Netherlands.
Albert GuskovGroningen Institute for Biomolecular Sciences and Biotechnology, University of Groningen, Groningen 9747AG, Netherlands.ORCID 0000-0003-2340-2216
Isobel NorvilleDSTL, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, United Kingdom.
Ute A HellmichInstitute of Organic Chemistry & Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstraße 10, Jena 07743, Germany.ORCID 0000-0001-7162-285X
Felix HauschDepartment of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, Darmstadt 64287, Germany.ORCID 0000-0002-3710-8838
Mitali Sarkar-TysonMarshall Centre for Infectious Diseases Research and Training, School of Biomedical Sciences, University of Western Australia, 35 Stirling Highway, Perth 6009, Australia.
Christoph SotrifferInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg, 97074, Germany.
Ulrike HolzgrabeInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg, 97074, Germany.ORCID 0000-0002-0364-7278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since Chagas disease, melioidosis, and Legionnaires' disease are all potentially life-threatening infections, there is an urgent need for new treatment strategies. All causative agents,

Indexed as

Bacterial ProteinsBurkholderia pseudomalleiLegionella pneumophilaMolecular Docking SimulationTrypanosoma cruziHumansMolecular Dynamics SimulationPeptidylprolyl IsomeraseProtozoan ProteinsStructure-Activity RelationshipBacterial ProteinsMip protein, Legionella pneumophilaPeptidylprolyl IsomeraseProtozoan ProteinsFKBP, halogen bondfluorescence polarization assaymacrophage infectivity potentiator proteinquantum mechanical calculationsstructure−activity relationship

Identifiers

PMID39357850
PMCPMC11476723

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.