ArticleInternational journal of radiation oncology, biology, physics2025
Deep Learning-Based Synthetic Computed Tomography for Low-Field Brain Magnetic Resonance-Guided Radiation Therapy.
Article in International journal of radiation oncology, biology, physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Research progress in artificial intelligence for brain metastases.Frontiers in medicine · 2025Review
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7 authors.
Funding
Abstract
purposeMagnetic resonance (MR)-guided radiation therapy enables online adaptation to address intra- and interfractional changes. To address the need of high-fidelity synthetic computed tomography (synCT) required for dose calculation, we developed a conditional generative adversarial network for synCT generation from low-field MR imaging in the brain. METHODS AND MATERIALS: Simulation MR-CT pairs from 12 patients with glioma imaged with a head and neck surface coil and treated on a 0.35T MR-linac were prospectively included to train the model consisting of a 9-block residual network generator and a PatchGAN discriminator. Four-fold cross-validation was implemented. SynCT was quantitatively evaluated against real CT using mean absolute error (MAE), peak signal-to-noise ratio (PSNR), and structural similarity index measure (SSIM). Dose was calculated on synCT applying original treatment plan. Dosimetric performance was evaluated by dose-volume histogram metric comparison and local 3-dimensional gamma analysis. To demonstrate utilization in treatment adaptation, longitudinal synCTs were generated for qualitative evaluation, and 1 offline adaptation case underwent 2 comparative plan evaluations. Secondary validation was conducted with 9 patients on a different MR-linac using a high-resolution brain coil.
resultsOur model generated high-quality synCTs with MAE, PSNR, and SSIM of 70.9 ± 10.4 HU, 28.4 ± 1.5 dB, and 0.87 ± 0.02 within the field of view, respectively. Underrepresented postsurgical anomalies challenged model performance. Nevertheless, excellent dosimetric agreement was observed with the mean difference between real and synCT dose-volume histogram metrics of -0.07 ± 0.29 Gy for target D
conclusionsOur conditional generative adversarial network model generated high-fidelity brain synCTs from low-field MR imaging with excellent dosimetric performance. Secondary validation suggests great promise of implementing synCTs to facilitate robust dose calculation for online adaptive brain MR-guided radiation therapy.
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