ArticleRevista da Associacao Medica Brasileira (1992)2024
The role of first-trimester systemic immune-inflammation index for the prediction of gestational diabetes mellitus.
Article in Revista da Associacao Medica Brasileira (1992), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Decoding inflammation: first-trimester biomarkers as predictive tools for gestational diabetes.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Longitudinal Assessment of Routine Blood-Derived Inflammatory Indices in Women with Diet-Controlled Gestational Diabetes: A Retrospective Study.International journal of women's health · 2026Article
- Comparison of Interpretable Machine Learning Models Using Systemic Inflammation Index to Predict Preterm Birth in Gestational Diabetes Mellitus.International journal of women's health · 2026Article
- Association of Early Pregnancy Inflammatory Indices with Preterm Birth and Perinatal Outcomes in Pregnancies with Pregestational Diabetes.Journal of clinical medicine · 2025Article
- The predictive value of serum MHR combined with classical metabolic syndrome components in the first trimester for gestational metabolic syndrome: a prospective cohort study in China.Frontiers in medicine · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
objectiveThe aim of this study was to investigate the role of systemic immune-inflammation index, neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, and platelet-lymphocyte ratios calculated in the first trimester as inflammatory markers in predicting gestational diabetes mellitus diagnosis.
methodsThis study was conducted retrospectively at a tertiary center between January 2020 and June 2023. A total of 111 pregnant women with gestational diabetes and 378 pregnant women in the control group were included in the study. Systemic immune-inflammation index, neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, and platelet-lymphocyte ratios values were compared between the gestational diabetes mellitus group patients and the healthy group. Receiver operating characteristic analysis curve was used for predicting gestational diabetes mellitus using systemic immune-inflammation index and lymphocyte-monocyte ratio.
resultsIn pregnant women in the first trimester, systemic immune-inflammation index and lymphocyte-monocyte ratio values based on routine complete blood count parameters were found to be statistically significantly higher in gestational diabetes mellitus patients compared to healthy patients, while neutrophil-lymphocyte ratio and platelet-lymphocyte ratios values were found to be similar (p=0.033, p=0.005, p=0.211, and p=0.989). For predicting gestational diabetes mellitus, a cut-off value of 655.75 for systemic immune-inflammation index resulted in 80.2% sensitivity and 34.4% specificity, and a cut-off value of 3.62 for lymphocyte-monocyte ratio resulted in 56.8% sensitivity and 63.2% specificity, indicating good discriminatory ability.
conclusionWe believe that systemic immune-inflammation index and lymphocyte-monocyte ratio values measured in the first-trimester complete blood count parameters are effective in predicting gestational diabetes mellitus but are not effective in determining insulin requirement.
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